Publications by authors named "Pablo Laufer"

Opportunistic infections most often occur in immunocompromised patients, however, they can also occur in immunocompetent patients. While rare, bacterial infections such as those from  () can cause severe pyogenic infections and abscess formations. It is important to understand the risk factors, diagnostic workup, and management of patients with this rare but enduring bacterial infection.

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Article Synopsis
  • Urinary tract infections (UTIs) are a leading cause of hospitalization in children, with an increasing presence of extended-spectrum beta-lactamase (ESBL) producing bacteria.
  • A study was conducted analyzing medical records of hospitalized children from 2014 to 2017 to identify risk factors and treatment outcomes for those with ESBL-UTI versus non-ESBL UTIs.
  • Key risk factors for ESBL-UTI identified were previous UTIs, recent antibiotic use, urinary abnormalities, past hospitalizations, and certain health issues, with patients typically needing longer treatment and hospitalization.
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Purpose: To report a case of a central retinal vein occlusion (CRVO) associated with COVID-19 in a patient predisposed to clotting due to a genetic mutation in methylenetetrahydrofolate reductase (MTHFR).

Observations: A 15-year-old male presented with 1 day of painless blurry vision in the left eye. Exam disclosed trace anterior chamber cell, anterior vitreous cell, optic nerve head edema, temporally displaced macular star, dilated tortuous veins, and diffuse intraretinal hemorrhages.

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Device-related thrombosis and device-related endocarditis after atrial septal defect (ASD) transcatheter closure are extremely rare. It is known that COVID-19 infection could lead to a thrombotic microangiopathy-like phenomenon. We present the case of a 14-year-old female who developed fever and was found to have a thrombus on the right atrial side of the ASD closure device weeks after an asymptomatic COVID-19 infection and negative COVID-19 test 2 days before transcatheter ASD closure.

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Synopsis of recent research by authors named "Pablo Laufer"

  • Pablo Laufer's recent research focuses on the impact of opportunistic infections, particularly in immunocompetent individuals, as illustrated by a case report detailing liver and bilateral tubo-ovarian abscesses caused by Streptococcus constellatus in an adolescent.
  • Laufer conducted a case-control study to evaluate risk factors and treatment outcomes for children hospitalized with extended-spectrum beta-lactamase-producing urinary tract infections (ESBL-UTI), highlighting a growing concern over antibiotic resistance in pediatric care.
  • His investigations also explore potential complications arising from COVID-19, including thrombotic events in pediatric patients, as evidenced by cases of central retinal vein occlusion and device-related thrombosis following infection, emphasizing the need for heightened awareness in clinical settings.