Publications by authors named "Pablo Iturrieta"
Stroke is the leading cause of neurological disability in people over 40 years of age and the fourth leading cause of death in Argentina. In the last ten years, the indexed publications related to the treatment of ischemic stroke were more numerous than those of hemorrhagic stroke. The objective of this material is to provide local and updated recommendations for the management of patients with spontaneous intracerebral hemorrhage during hospitalization.
View Article and Find Full Text PDFRationale: Cyclic strain may be a determinant of ventilator-induced lung injury. The standard for strain assessment is the computed tomography (CT), which does not allow continuous monitoring and exposes to radiation. Electrical impedance tomography (EIT) is able to monitor changes in regional lung ventilation.
View Article and Find Full Text PDFDeterioration of lung function during the first week of COVID-19 has been observed when patients remain with insufficient respiratory support. Patient self-inflicted lung injury (P-SILI) is theorized as the responsible, but there is not robust experimental and clinical data to support it. Given the limited understanding of P-SILI, we describe the physiological basis of P-SILI and we show experimental data to comprehend the role of regional strain and heterogeneity in lung injury due to increased work of breathing.
View Article and Find Full Text PDFArticle Synopsis
- Protective mechanical ventilation (MV) can improve clinical outcomes in ARDS by limiting lung deformation, but its effects on spontaneously breathing injured lungs are less understood.
- A study using murine models analyzed lung strain after inducing injury, comparing spontaneous breathing (SB) and low-volume MV over a 3-hour period.
- Results showed that SB led to significant increases in regional strain and heterogeneity, while MV limited these effects, suggesting MV is more effective in preventing lung deformation in injured lungs.
Introduction: Breathing produces a phenomenon of cyclic deformation throughout life. Biomechanically, deformation of the lung is measured as strain. Regional strain recently started to be recognised as a tool in the study of lung pathophysiology, but regional lung strain has not been studied in healthy subjects breathing spontaneously without voluntary or pharmacological control of ventilation.
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