Publications by authors named "Pablo Hernandez-Ortego"
TRPM8 is a non-selective cation channel expressed in primary sensory neurons and other tissues, including the prostate and urothelium. Its participation in different physiological and pathological processes such as thermoregulation, pain, itch, inflammation and cancer has been widely described, making it a promising target for therapeutic approaches. The detection and quantification of TRPM8 seems crucial for advancing the knowledge of the mechanisms underlying its role in these pathophysiological conditions.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of the TRPM8 ion channel, known for sensing cold, in regulating circadian functions in mammals, particularly concerning body temperature and internal biological clocks.
- Researchers used specific mouse models to observe TRPM8's expression in various tissues and its effects on circadian rhythms and temperature regulation.
- Results showed that TRPM8 is crucial for maintaining stable circadian rhythms and temperature oscillations; its deficiency led to disrupted clock gene expression and altered body temperature patterns.
The cold- and menthol-activated ion channel transient receptor potential channel subfamily M member 8 (TRPM8) is the principal detector of environmental cold in mammalian sensory nerve endings. Although it is mainly expressed in a subpopulation of peripheral sensory neurons, it has also been identified in non-neuronal tissues. Here, we show, by in situ hybridization (ISH) and by the analysis of transgenic reporter expression in two different reporter mouse strains, that TRPM8 is also expressed in the central nervous system.
View Article and Find Full Text PDF