Polymorphic forms of bendamustine hydrochloride: crystal structure, thermal properties and stability at ambient conditions.

Crystallographic, thermal and stability analyses are presented of three different anhydrated forms of bendamustine hydrochloride [(I), (III) and (IV)] and a fourth, monohydrated one (II). Since form (I) presents the higher melting point and the higher heat of fusion, according to the `heat of fusion' rule it should be the most stable in thermodynamic terms [Burger & Ramberger (1979). Mikrochim.

Thermal, spectroscopic and structural analysis of a thermosalient phase transformation in tapentadol hydrochloride.

Presented herein are detailed optical, thermal, spectroscopic and structural analyses of the phase transformation occurring in tapentadol hydrochloride (CHNO·Cl), a phenomenon already reported [Fischer et al. (2006); Patent: WO 2006000441 A2]. The thermal behaviour of the compound was studied using single-crystal X-ray diffraction, differential scanning calorimetry and Raman scattering measurements.

A crystallographic and thermal study of pridinol mesylate and its monohydrated solvate.

Herein are reported the crystal and molecular structures of the pridinol mesylate salt (CHNO·CHOS) (I) and its monohydrated solvate form (CHNO·CHOS·HO) (II). A comparison of both with the already reported structure of pure pridinol [1,1-diphenyl-3-piperidino-1-propanol, CHNO; Tacke et al. (1980).