Publications by authors named "Pablo Cresta"
Extracellular vesicles (EVs) secreted by tumors are abundant in plasma, but their potential for interrogating the molecular features of tumors through multi-omic profiling remains widely unexplored. Genomic and transcriptomic profiling of circulating EV-DNA and EV-RNA isolated from in vitro and in vivo models of metastatic prostate cancer (mPC) reveal a high contribution of tumor material to EV-loaded DNA/RNA, validating the findings in two cohorts of longitudinal plasma samples collected from patients during androgen receptor signaling inhibitor (ARSI) or taxane-based therapy. EV-DNA genomic features recapitulate matched-patient biopsies and circulating tumor DNA (ctDNA) and associate with clinical progression.
View Article and Find Full Text PDFSpecific nutritional supplement (Supportan®) in the supportive care of the radio-chemotherapy treatment of head and neck cancers: biochemical parameters. Preliminary study.
Endocr Metab Immune Disord Drug Targets
December 2013
Article Synopsis
- This study focuses on the nutritional supplement Supportan(®) aimed at supporting patients with advanced head and neck cancers undergoing concurrent radiochemotherapy (RT-CHT).
- Seven patients participated, receiving the supplement alongside their regular diet for an average of 7.8 weeks of treatment, allowing researchers to evaluate the effectiveness of the nutritional support.
- Results showed that all patients completed their treatment without severe complications or deterioration in health status, indicating that Supportan(®) may help maintain nutritional levels during aggressive cancer therapy.