Publications by authors named "Pablo Augustin Vargas"
Chronic Sclerosing Sialadenitis of the Submandibular Gland and its Histopathological Spectrum in the IgG4-Related Disease: a Series of 17 Cases.
Head Neck Pathol
May 2024
Article Synopsis
- This study investigated chronic sclerosing sialadenitis (CSS) to explore its histopathological and immunohistochemical features, with a focus on IgG4-related disease (IgG4-RD).
- Out of 17 cases examined, the majority showed inflammatory and fibrotic changes, with notable presence of CD3-positive T lymphocytes and stromal fibroblasts, but only three cases met IgG4-RD criteria.
- The findings suggest that CSS in the submandibular gland is primarily a reactive condition rather than directly related to IgG4-RD, providing valuable insights into its characteristics and immunological profile.
Merkel cell carcinoma (MCC) is an aggressive and rare cutaneous neuroendocrine carcinoma that predominantly affects the sun-damaged skin of the head and neck region, extremities, and trunk of older white individuals. Microscopically, MCC is characterized by nests or sheets of uniform small round blue cells with scant cytoplasm, granular nuclei with a salt-and-pepper chromatin pattern, high proliferative activity, and occasional necrosis. They are usually positive for epithelial and neuroendocrine markers, particularly for cytokeratin 20 and AE1/AE3 in a paranuclear dot-like staining.
View Article and Find Full Text PDFMelanotic neuroectodermal tumor of infancy (MNTI) is a rare neoplasm that affects mainly children under 1 year of age. A 4-month-old boy was referred for evaluation of a lesion with 1 month of evolution. Intra-oral examination detected a firm upon palpation submucosal nodular mass, measuring 1.
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