Reproductive and pregnancy control in Wilson disease patients in Spain.

Background And Aim: Recommendations on pregnancy, lactation, and contraception in women with Wilson disease are briefly stated in international guidelines but are not entirely homogeneous. Data regarding the management of these special events among patients with Wilson disease in Spain are lacking. We used the Wilson Registry platform of the Spanish Association for the Study of the Liver to question patients on their reproductive and gestational lives.

Implementing living evidence to inform health decisions: A strategy for building capacity in health sector (Protocol).

Every day important healthcare decisions are made with incomplete or outdated information about the effects of the healthcare interventions available, what delivers the best value for the health system and where more research is needed. It is necessary to invest in strategies that allow access to reliable and updated evidence on which to base health decisions. The objective is to develop and evaluate a strategy for building the capacity among different actors of a country's health system to implement the model known as "Living Evidence" [LE] in the evidence synthesis and dissemination of knowledge transfer [KT] products to inform health decisions.

Methodological approaches for developing and reporting living evidence synthesis: a study protocol.

: Living evidence (LE) refers to the methodological processes that permit new research findings to be continually incorporated into evidence synthesis. This approach is of great value in the resolution of relevant and rapidly changing clinical questions. To date, the methods to carry out this type of synthesis are not completely defined, and great variability is observed in the approaches used by different groups of authors.

Magnetic, Mechanically Interlocked Porphyrin-Carbon Nanotubes for Quantum Computation and Spintronics.

Atomic-scale reproducibility and tunability endorse magnetic molecules as candidates for spin qubits and spintronics. A major challenge is to implant those molecular spins into circuit geometries that may allow one, two, or a few spins to be addressed in a controlled way. Here, the formation of mechanically bonded, magnetic porphyrin dimeric rings around carbon nanotubes (mMINTs) is presented.

Slow Magnetic Relaxation in {[CoCxAPy)] 2.15 HO} MOF Built from Ladder-Structured 2D Layers with Dimeric SMM Rungs.

We present the magnetic properties of the metal-organic framework {[CoCxAPy]·2.15 HO} (Cx = bis(carboxypropyl)tetramethyldisiloxane; APy = 4,4`-azopyridine) () that builds up from the stacking of 2D coordination polymers. The 2D-coordination polymer in the plane is formed by the adjacent bonding of [CoCxAPy] 1D two-leg ladders with Co dimer rungs, running parallel to the -axis.

Broad-band spectroscopy of a vanadyl porphyrin: a model electronuclear spin qudit.

We explore how to encode more than a qubit in vanadyl porphyrin molecules hosting a = 1/2 electronic spin coupled to a = 7/2 nuclear spin. The spin Hamiltonian and its parameters, as well as the spin dynamics, have been determined a combination of electron paramagnetic resonance, heat capacity, magnetization and on-chip magnetic spectroscopy experiments performed on single crystals. We find low temperature spin coherence times of micro-seconds and spin relaxation times longer than a second.

A dissymmetric [Gd] coordination molecular dimer hosting six addressable spin qubits.

Artificial magnetic molecules can host several spin qubits, which could then implement small-scale algorithms. In order to become of practical use, such molecular spin processors need to increase the available computational space and warrant universal operations. Here, we design, synthesize and fully characterize dissymetric molecular dimers hosting either one or two Gadolinium(III) ions.

A heterometallic [LnLn'Ln] lanthanide complex as a qubit with embedded quantum error correction.

We show that a [Er-Ce-Er] molecular trinuclear coordination compound is a promising platform to implement the three-qubit quantum error correction code protecting against pure dephasing, the most important error in magnetic molecules. We characterize it by preparing the [Lu-Ce-Lu] and [Er-La-Er] analogues, which contain only one of the two types of qubit, and by combining magnetometry, low-temperature specific heat and electron paramagnetic resonance measurements on both the elementary constituents and the trimer. Using the resulting parameters, we demonstrate by numerical simulations that the proposed molecular device can efficiently suppress pure dephasing of the spin qubits.

A bis-vanadyl coordination complex as a 2-qubit quantum gate.

A new bis-hydroxyphenylpyrazolyl ligand, HL, allows isolating and structurally characterizing vanadyl and titanyl dinuclear complexes (BuN)[(MO)(HL)] (M = V, Ti). The weak dipolar coupling and relatively short quantum coherence of the divanadyl anions are optimal for a 2-qubit molecular architecture proposed to implement electron-mediated nuclear quantum simulations.

M-C Bond Homolysis in Coinage-Metal [M(CF ) ] Derivatives.

A comparative study of the homoleptic [M(CF ) ] complexes of all three coinage metals (M=Cu, Ag, Au) reveals that homolytic M-C bond cleavage is favoured in every case upon excitation in the gas phase (CID-MS ). Homolysis also occurs in solution by photochemical excitation. Transfer of the photogenerated CF radicals to both aryl and alkyl carbon atoms was also confirmed.

Effectiveness and limitations of an incident-reporting system analyzed by local clinical safety leaders in a tertiary hospital: Prospective evaluation through real-time observations of patient safety incidents.

The effectiveness of a hospital incident-reporting system (IRS) on improve patient safety is unclear. This study objective was to assess which implemented improvement actions after the analysis of the incidents reported were effective in reduce near-misses or adverse events.Patient safety incidents (PSIs), near misses and adverse events, notified to the IRS were analyzed by local clinical safety leaders (CSLs) who propose and implement improvement actions.

Correction: Magnetic properties of the seven-coordinated nanoporous framework material Co(bpy)(NO) (bpy = 4,4'-bipyridine).

Correction for 'Magnetic properties of the seven-coordinated nanoporous framework material Co(bpy)1.5(NO3)2 (bpy = 4,4'-bipyridine)' by Elena Bartolomé et al., Dalton Trans.

The photosynthetic cytochrome c from the diatom Phaeodactylum tricornutum.

The photosynthetic cytochrome c from the marine diatom Phaeodactylum tricornutum has been purified and characterized. Cytochrome c is mostly obtained from the soluble cell extract in relatively large amounts. In addition, the protein appeared to be truncated in the last hydrophobic residues of the C-terminus, both in the soluble cytochrome c and in the protein extracted from the membrane fraction, as deduced by mass spectrometry analysis and the comparison with the gene sequence.

Slow magnetic relaxation in a dimeric MnCa complex enabled by the large Mn(iii) rhombicity.

In this paper we present the characterization of a complex with the formula [MnCa(hmp)(HO)(CHCN)](ClO) (1), where hmp-H = 2-(hydroxymethyl)pyridine. Compound 1 crystallizes in the monoclinic space group C2/c with the cation lying on an inversion centre. Static magnetic susceptibility, magnetization and heat capacity measurements reflect a unique Mn(iii) valence state, and single-ion ligand field parameters with remarkable large rhombic distortion (D/k = -6.

Anatomical-Ultrasound Visor for Regional Anaesthesia.

Introduction: Regions considered optimal for performing peripheral nerve blocking have been well documented. However identify and perform regional anesthesia in those regions from ultrasound images remains a challenge.

Aim: This study aims to develop a virtual environment for the simulation of ultrasound exploration of the neck nerves and both the upper and lower limbs for regional anesthesia.

Spin Densities in Flavin Analogs within a Flavoprotein.

Characterization by electron paramagnetic resonance techniques of several variants of Anabaena flavodoxin, where the naturally occurring FMN cofactor is substituted by different analogs, makes it possible to improve the details of the spin distribution map in the isoallosazine ring in its semiquinone state. The analyzed variants were selected to monitor the effects of intrinsic changes in the flavin ring electronic structure, as well as perturbations in the apoflavodoxin-flavin interaction, on the spin populations. When these effects were analyzed together with the functional properties of the different flavodoxin variants, a relationship between spin population and biochemical parameters, as the reduction potential, could be envisaged.

Treatment of Anxiety Disorders in a Psychology Clinic.

People with anxiety disorders demand psychological attention most often. Therefore, it seems important to identify both the characteristics of the patients who demand help and the clinical variables related to that demand and its treatment. A cohort of 292 patients who requested help at a university clinical facility was studied.

In vivo reconstitution of a homodimeric cytochrome b559 like structure: The role of the N-terminus α-subunit from Synechocystis sp. PCC 6803.

The cytochrome b559 is a heme-bridged heterodimeric protein with two subunits, α and β. Both subunits from Synechocystis sp. PCC 6803 have previously been cloned and overexpressed in Escherichia coli and in vivo reconstitution experiments have been carried out.

Nonconvulsive status epilepticus secondary to paclitaxel administration.

Nonconvulsive status epilepticus (NCSE) can be triggered by metabolic disturbances and drugs in adults without previous epilepsy. We present the case of a 51-year-old woman without previous history of epilepsy and recently diagnosed with infiltrating lobular breast carcinoma. Following the administration of paclitaxel-cremophor, she presented a striking disinhibited behavior with episodic spatial disorientation, emotional indifference, and irritability.

Methyl rotors in flavoproteins.

In this contribution we present the study of the thermal dependence of the ENDOR spectra of flavodoxin at low temperatures which reveals the dynamics of the methyl groups bound to the flavin moiety in flavoproteins. The methyl groups behave as quantum rotors locked by a deep rotational well and undergoing a tunneling process. At room temperature, methyl rotors are locked and the hopping motion is slow.

Homoleptic organocobalt(III) compounds with intermediate spin.

Homoleptic organocobalt(III) compounds with formula [NBu4][Co(III)(C6X5)4] [X = F (3), Cl (4)] were obtained in reasonable yields by chemical oxidation of the corresponding divalent species [NBu4]2[Co(II)(C6X5)4] [X = F (1), Cl (2)]. The [Co(III)(C6X5)4](-)/[Co(II)(C6X5)4](2-) couples are electrochemically related by quasi-reversible, one-electron exchange processes at moderate potential: E1/2 = -0.29 (X = F) and -0.

Heterodimetallic [LnLn'] lanthanide complexes: toward a chemical design of two-qubit molecular spin quantum gates.

A major challenge for realizing quantum computation is finding suitable systems to embody quantum bits (qubits) and quantum gates (qugates) in a robust and scalable architecture. An emerging bottom-up approach uses the electronic spins of lanthanides. Universal qugates may then be engineered by arranging in a molecule two interacting and different lanthanide ions.

Origin of slow magnetic relaxation in Kramers ions with non-uniaxial anisotropy.

Transition metal ions with long-lived spin states represent minimum size magnetic bits. Magnetic memory has often been associated with the combination of high spin and strong uniaxial magnetic anisotropy. Yet, slow magnetic relaxation has also been observed in some Kramers ions with dominant easy-plane magnetic anisotropy, albeit only under an external magnetic field.