A retrospective study of oral lichen planus patients with concurrent or subsequent development of malignancy.

Oral lichen planus (OLP) carries a very small probability of becoming malignant. Our Finnish series comprised eight patients suffering from OLP and concurrent or subsequent oral squamous cell carcinoma over a 10-year period. The mean interval between the histologically suggested initial diagnosis of OLP and carcinoma was 3.

[Binding of (3)-imipramine by platelets from spontaneously hypertensive, normotensive, and Wistar rats and their behavior in stressful situations].

Spontaneously hypertensive rats (SHR), when submitted to stress remained active during both avoidance (water escape task test) and nonavoidance (forced swimming test) stress-situations. Wistar rats responded to a depression of active behaviour in forced swimming test and difficulty at resolving of complicated problem in water escape task test. did not differ in the affinity but the number of binding sites of 3H-imipramine was greater in SHR.

Taurine in the osmoregulation of the Brattleboro rat.

The function of taurine in mammalian osmoregulation was studied in the Brattleboro rat with hereditary hypothalamic diabetes insipidus (DI). DI rats are chronically dehydrated because of their inability to synthesize vasopressin. One day of water deprivation did not affect the water balance in rats with normal vasopressin synthesis, whereas DI rats were markedly dehydrated and lost considerably body weight.

Effect of acetylsalicylic acid on plasma thromboxane B2 and platelet aggregation in man.

The effect of acetylsalicylic acid (ASA) on plasma thromboxane A2 (TXA2) and platelet aggregation was studied in 12 healthy, non-smoking, male students, in a double-blind, cross-over study, after single doses and 14-days on ASA 50, 100, 250 and 1000 mg/day. Platelet production of TXA2 was assessed by measuring the thromboxane B2 (TXB2) content of clotted venous blood by RIA. Platelet aggregation induced by ADP and adrenaline was studied by the method of Born.

Cardiovascular and ventilatory effects of taurine and homotaurine in anaesthetized rats.

The cardiovascular and ventilatory effects of intravenous (i.v.) or intracerebroventricular (i.

Taurine in human auricular myocardium and blood platelets.

Blood platelets have been used as a model for the aminergic neurones. In the hypertrophied left ventriles and platelets of spontaneously hypertensive rats the taurine content increases simultaneously. The main purpose of this work was to compare the taurine contents of human platelets and heart tissue.

beta-Alanine and alpha-L-alanine inhibit the exploratory activity of spontaneously hypertensive rats.

1% beta-alanine and alpha-L-alanine, when given for 7 days as the only drinking fluid, inhibited the exploratory activity of adult male spontaneously-hypertensive rats (SHR) but not that of the normotensive Wistar-Kyoto rats (WKR). beta-Alanine decreased the taurine level in the liver of both strains and in the platelets of SHR. alpha-Alanine decreased the taurine level in the liver of WKR and in the platelets of SHR.

Platelet taurine in patients with arterial hypertension, myocardial failure or infarction.

The content of taurine in the hypertrophied left ventricle is increased in congestive heart failure an in spontaneously hypertensive (SH) rats. In SH rats the taurine content of and taurine uptake by the platelets are also increased. The present results indicate that, as in the heart, the taurine content may also increase in the platelets of those patients with congestive heart failure.

Platelet taurine in Down's syndrome.

Endogenous platelet taurine and uptake of radioactively labelled taurine by platelets was measured in normal, non-mongoloid and mentally retarded mongoloid trisomy 21 subjects. Endogenous taurine was normal in all groups, while taurine transport kinetic experiments showed normal Km but reduced Vmax in mongoloid trisomy 21 and mentally retarded patients. The latter difference may be due to decreased metabolism following decreased enzyme protein synthesis.

Transport of taurine by normal human blood platelets.

1 Because normal human blood platelets contain higher concentrations of taurine than any other amino acid, and have a platelet: plasma concentration gradient exceeding 400: 1, we isolated the cells in vitro and incubated them with radioactively labelled taurine in order to investigate the existence of a metabolically-dependent accumulation process.2 Platelets incubated with taurine (1 to 100 nmol/ml) in autologous plasma or Krebs solution accumulated [(14)C]-taurine against the concentration gradient.3 The transport process was saturable at high concentrations, showed a requirement for sodium ions, and was temperature-dependent.