Publications by authors named "Paarthiphan Elankumaran"
Extraintestinal pathogenic (ExPEC) sequence type (ST) 38 is one of the top 10 human pandemic lineages. Although a major cause of urinary tract and blood stream infections, ST38 has been poorly characterized from a global phylogenomic perspective. A comprehensive genome-scale analysis of 925 ST38 isolate genomes identified two broad ancestral clades and linkage of discrete ST38 clusters with specific variants.
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- Extraintestinal pathogenic Escherichia coli (ExPEC) are a leading cause of urinary tract infections (UTIs), with a study analyzing 320 isolates from urine samples revealing that most were not chosen based on antimicrobial resistance (AMR) characteristics.
- Whole genome sequencing (WGS) identified 88 sequence types (STs), with ST73, ST95, ST127, and ST131 being the most prevalent, while the presence of virulence plasmids indicated a complex relationship between virulence and antibiotic resistance.
- F plasmids varied in their antibiotic resistance gene (ARG) content, with pUTI89-like plasmids showing fewer ARGs compared to non-pUTI89-like plasmids, and the phylogenomic analysis suggested
Companion animals and humans are known to share extraintestinal pathogenic Escherichia coli (ExPEC), but the extent of E. coli sequence types (STs) that cause extraintestinal diseases in dogs is not well understood. Here, we generated whole-genome sequences of 377 ExPEC collected by the University of Melbourne Veterinary Hospital from dogs over an 11-year period from 2007 to 2017.
View Article and Find Full Text PDFST127, a recently emerged global pathogen noted for high virulence gene carriage, is a leading cause of urinary tract and blood stream infections. ST127 is frequently isolated from humans and companion animals; however, it is unclear if they are distinct or related populations of ST127. We performed a phylogenomic analysis of 299 ST127 of diverse epidemiological origin to characterize their population structure, genetic determinants of virulence, antimicrobial resistance, and repertoire of mobile genetic elements with a focus on plasmids.
View Article and Find Full Text PDFST131 is a globally dispersed extraintestinal pathogenic lineage contributing significantly to hospital and community acquired urinary tract and bloodstream infections. Here we describe a detailed phylogenetic analysis of the whole genome sequences of 284 Australian ST131 isolates from diverse sources, including clinical, food and companion animals, wildlife and the environment. Our phylogeny and the results of single nucleotide polymorphism (SNP) analysis show the typical ST131 clade distribution with clades A, B and C clearly displayed, but no niche associations were observed.
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