Publications by authors named "PW Park"

Article Synopsis
  • The study examined how the severity and direction of residual aortic regurgitation (rAR) after valve-sparing root replacement (VSRR) affects patient outcomes.
  • It involved 248 adult patients, focusing on the development of significant aortic regurgitation or the need for valve replacement during follow-up.
  • Results showed that while most patients with rAR had minimal forms, those with eccentric rAR were at a higher risk for progression, suggesting the need for ongoing monitoring and potential early intervention.
View Article and Find Full Text PDF
Article Synopsis
  • This study explored how early diagnosis (ED) of Loeys-Dietz syndrome (LDS) impacts surgical outcomes in patients undergoing aortic surgery.
  • The research involved a review of 38 LDS patients, comparing those diagnosed before surgery (ED group) to those diagnosed afterward (DD group).
  • Results showed that the ED group had fewer emergency surgeries, shorter hospital stays, and a lower reoperation rate, highlighting the benefits of early diagnosis for better patient outcomes.
View Article and Find Full Text PDF

A large number of bacterial pathogens bind to host extracellular matrix (ECM) components. For example, many Gram-negative and Gram-positive pathogens express binding proteins for fibronectin (FN) on their cell surface. Mutagenesis studies of bacterial FN-binding proteins have demonstrated their importance in pathogenesis in preclinical animal models.

View Article and Find Full Text PDF

Background: We aimed to analyze the impact of concomitant Maze procedure on the clinical and rhythm outcomes, and echocardiographic parameters in tricuspid repair for patients with severe tricuspid regurgitation (TR) and persistent atrial fibrillation (AF).

Methods: Patients who had severe TR and persistent AF and underwent tricuspid valve (TV) repair were included in the study. Both primary TR and secondary TR were included in the current study.

View Article and Find Full Text PDF

The increasing use of sodium glucose transporter 2 inhibitors (SGLT2i) for treating cardiovascular (CV) diseases and type 2 diabetes (T2D) is accompanied by a rise in euglycemic diabetic ketoacidosis occurrences in cardiac surgery patients. Patients undergoing cardiac surgery, due to their pre-existing CV disease which often requires SGLT2i prescriptions, face an increased risk of postoperative metabolic acidosis (MA) or ketoacidosis (KA) associated with SGLT2i, compounded by fasting and surgical stress. The primary aim of this study is to quantify the incidence of SGLT2i-related postoperative MA or KA and to identify related risk factors.

View Article and Find Full Text PDF

Objective: To create a data-driven definition of post-COVID conditions (PCC) by directly measure changes in symptomatology before and after a first COVID episode.

Materials And Methods: Retrospective cohort study using Optum® de-identified Electronic Health Record (EHR) dataset from the United States of persons of any age April 2020-September 2021. For each person with COVID (ICD-10-CM U07.

View Article and Find Full Text PDF
Article Synopsis
  • * A study of 24 pediatric patients over a median of 8.3 years found a strong 15-year survival rate of 91.7%, but 29.1% faced reoperations for aortic aneurysm or dissection within 10 years.
  • * The research highlighted that younger age at the time of surgery is linked to higher risks of complications, suggesting that ongoing monitoring is crucial, especially for patients who underwent VSRR before age 13.
View Article and Find Full Text PDF

Objective: The Electronic Chronic Pain Questions (eCPQ) has been developed to help healthcare providers systematically capture chronic pain data. This study evaluated the impact of using the eCPQ on patient-reported outcomes (PROs) and healthcare resource utilization (HCRU) in a primary care setting, and patient and physician perceptions regarding use of, and satisfaction with, the eCPQ.

Methods: This was a prospective pragmatic study conducted at the Internal Medicine clinic within the Henry Ford Health (HFH) Detroit campus between June 2017 and April 2020.

View Article and Find Full Text PDF

Receptor-ligand interactions play an important role in many biological processes by triggering specific cellular responses. These interactions are frequently regulated by coreceptors that facilitate, alter, or inhibit signaling. Coreceptors work in parallel with other specific and accessory molecules to coordinate receptor-ligand interactions.

View Article and Find Full Text PDF

Background: Cryoablation is effective for not only ablating the myocardium, but also maintaining the structure of the ablated tissue. However, data comparing nitrous oxide (NO)-based and argon gas-based cryoprobes are limited.

Methods: This study was a follow-up study of a single-center, prospective, randomized controlled trial in which 60 patients were randomly allocated to either the NO group or the argon group.

View Article and Find Full Text PDF

Objective: Patients with severe tricuspid regurgitation and persistent atrial fibrillation may not be good candidates for maze procedure due to preoperative atrial remodeling and various comorbidities. We attempted to evaluate the rhythm and clinical outcomes of maze procedure in these patients.

Methods: Patients with severe tricuspid regurgitation and persistent atrial fibrillation who underwent tricuspid valve surgery between January 1994 and December 2017 at a single tertiary center were analyzed.

View Article and Find Full Text PDF

Heparan sulfate proteoglycans (HSPGs) are at the forefront of host-microbe interactions. Cell surface HSPGs are thought to promote infection as attachment and internalization receptors for many bacterial pathogens and as soluble inhibitors of host immunity when released from the cell surface by ectodomain shedding. However, the importance of HSPG-pathogen interactions in vivo has yet to be clearly established.

View Article and Find Full Text PDF

Invariant NKT (iNKT) cells are potent immunomodulatory cells that acquire effector function during their development in the thymus. IL-17-producing iNKT cells are commonly referred to as NKT17 cells, and they are unique among iNKT cells to express the heparan sulfate proteoglycan CD138 and the transcription factor RORγt. Whether and how CD138 and RORγt contribute to NKT17 cell differentiation, and whether there is an interplay between RORγt and CD138 expression to control iNKT lineage fate, remain mostly unknown.

View Article and Find Full Text PDF

What Is Known And Objective: Age and gender have been reported to play a crucial role in modulating the disposition of pharmacological agents, and to influence the activities of cytochrome P450 (CYP) 2D6, a drug-metabolizing enzyme involved in the disposition of clinically used drugs. In the present study, the effects of age and gender on the CYP2D6 activity were evaluated using dextromethorphan as a probe drug in humans.

Methods: Healthy young (20 < age < 30 years, n = 60) and old age (age >60 years, n = 60) subjects were enrolled and were given 15 mg dextromethorphan orally.

View Article and Find Full Text PDF

Background: This study aimed to investigate the early and late outcomes of mechanical tricuspid valve replacement (mTVR).

Methods: We evaluated 113 patients (82 women; median age, 53 years) who underwent mTVR between 1995 and 2017. Based on a history of cardiac surgery, patients were divided into primary (n=42) and reoperative mTVR (n=71) groups.

View Article and Find Full Text PDF

Subversion of heparan sulfate proteoglycans (HSPGs) is thought to be a common virulence mechanism shared by many microbial pathogens. The prevailing assumption is that pathogens co-opt HSPGs as cell surface attachment receptors or as inhibitors of innate host defense. However, there are few data that clearly support this idea We found that deletion of syndecan-1 (Sdc1), a major cell surface HSPG of epithelial cells, causes a gain of function in a mouse model of scarified corneal infection, where corneas were significantly less susceptible to infection.

View Article and Find Full Text PDF

Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth is critical to better understanding how they are regulated. Here, we show that a knock-in reporter mouse for the stem cell gene Musashi 2 (Msi2) allows identification of leukemia stem cells in aggressive myeloid malignancies, and provides a strategy for defining their core dependencies.

View Article and Find Full Text PDF

A 59-year-old man presented for possible durable ventricular assist device (VAD) implantation. He had previously been diagnosed with congenitally corrected transposition of the great arteries, a ventricular septal defect, an atrial septal defect, pulmonary valve stenosis, and aortic valve regurgitation. In the previous 22 years, he had undergone palliative cardiac surgery 3 times.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the long-term effects of prophylactic tricuspid annuloplasty (TAP) in patients with mild tricuspid regurgitation (TR) after mitral valve repair.
  • A total of 151 patients were analyzed, divided into TAP and no TAP groups, with follow-up averaging over 9 years; statistical adjustments were made for baseline differences.
  • Results indicated no significant differences in survival, cardiac-related mortality, or TR progression between the two groups, suggesting that TAP may not offer additional benefits in this context.
View Article and Find Full Text PDF

Heparan sulfate proteoglycans (HSPGs) are at the forefront of host-microbe interactions. Molecular and cell-based studies suggest that HSPG-pathogen interactions promote pathogenesis by facilitating microbial attachment and invasion of host cells. However, the specific identity of HSPGs, precise mechanisms by which HSPGs promote pathogenesis, and the in vivo relevance of HSPG-pathogen interactions remain to be determined.

View Article and Find Full Text PDF

Acetaminophen/paracetamol (APAP) overdose is the leading cause of drug-induced acute liver failure (ALF) in the United States and Europe. The progression of the disease is attributed to sterile inflammation induced by the release of high mobility group box 1 (HMGB1) and the interaction with receptor for advanced glycation end products (RAGE). A specific, effective, and safe approach to neutralize the proinflammatory activity of HMGB1 is highly desirable.

View Article and Find Full Text PDF

Background: The present study aimed to compare the long-term clinical and hemodynamic outcomes of aortic valve replacement using Carpentier-Edwards Perimount (Perimount) or Perimount Magna (Magna) valves.

Methods: We enrolled 430 patients who underwent aortic valve replacements with Perimount (n=58) or Magna (n=372) valves [1998-2013]. Multivariable and inverse probability of treatment weight (IPTW) analyses were performed.

View Article and Find Full Text PDF

Background: Rapid and accurate diagnosis of acute myocardial infarction (AMI) is critical for initiating effective treatment and achieving better prognosis. We investigated the performance of copeptin for early diagnosis of AMI, in comparison with creatine kinase myocardial band (CK-MB) and troponin I (TnI).

Methods: We prospectively enrolled 271 patients presenting with chest pain (within six hours of onset), suggestive of acute coronary syndrome, at an emergency department (ED).

View Article and Find Full Text PDF

Background: Several reports described the repair of sinus of Valsalva aneurysms (SVAs); however, there is still debate regarding the optimal method of operation. We investigated the determinants of the development of significant aortic regurgitation (AR) and long-term survival after surgical repair.

Methods: Between January 1995 and December 2016, 71 patients (31 females; median age: 33.

View Article and Find Full Text PDF