Publications by authors named "PR Subramanian"
ACS Med Chem Lett
February 2023
Article Synopsis
- - B cell lymphoma 6 (BCL6) plays a crucial role in non-Hodgkin lymphoma, especially diffuse large B-cell lymphoma (DLBCL), and its function is influenced by interactions with co-repressors.
- - Researchers aimed to develop BCL6 inhibitors to create new treatment options for DLBCL by disrupting these co-repressor interactions, resulting in a significant virtual screening hit.
- - The most promising candidate, OICR12694/JNJ-65234637, has shown potent inhibition of DLBCL cell growth at low concentrations and demonstrates a favorable oral pharmacokinetic profile, making it a strong candidate for further testing, especially in combination therapies.
