Oral medications for the treatment of postural orthostatic tachycardia syndrome; a systematic review of studies before and during the COVID-19 pandemic.

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a complex form of dysautonomia that presents with abnormal autonomic reflexes upon standing, leading to symptoms such as lightheadedness, tachycardia, fatigue, and cognitive impairment. The COVID-19 pandemic has brought renewed attention to POTS due to its overlap with post-acute sequelae of COVID-19 (PASC). Studies have found that a substantial percentage of COVID-19 survivors exhibit symptoms resembling POTS, elevating POTS diagnoses to previously unseen levels.

Vasectomy incidence in the military health system after the reversal of Roe v. Wade.

Dobbs v. Jackson Women's Health Organization (Dobbs decision) has already had profound impact on reproductive health care in the United States. Some studies have reported increased incidence of vasectomy after the Dobbs decision.

A new method for quantifying Cu in nuclear debris samples.

Quantifying Cu in post-detonation nuclear debris samples can provide important diagnostic information regarding the structural materials used within a nuclear device. However, this task is challenging due to the weak gamma emissions associated with the decay of Cu, its short half-life (12.701 h), and the presence of interfering fission product radioisotopes.

Determination of the Tb half-life.

There is significant interest in the use of terbium radioisotopes for applications in cancer therapy and diagnosis. Of these, Tb, as a medium energy beta-emitter, is being investigated as a potential alternative to Lu. The relatively high proportion of conversion electron and Auger electron emissions per decay make Tb an attractive targeted therapeutic.

Safety and immunogenicity of an inactivated eastern equine encephalitis virus vaccine.

Background: Eastern equine encephalitis virus (EEEV) is a mosquito borne alphavirus spread primarily in Atlantic and Gulf Coast regions of the United States. EEEV is the causative agent of a devastating meningoencephalitis syndrome, with approximately 30% mortality and significant morbidity. There is no licensed human vaccine against EEEV.

The Western Equine Encephalitis Lyophilized, Inactivated Vaccine: An Update on Safety and Immunogenicity.

Background: Western Equine Encephalitis (WEE) is a naturally acquired infection and potentially devastating bioweapon, with no specific human countermeasures. An experimental inactivated Western Equine Encephalitis Vaccine (WEEV; WEE TSI-GSD 210) has been used under an IND (investigational New Drug) protocol at the United States Army Medical Research Institute of Infectious Diseases (USAMRIID) since 1976.

Methods: Over 24 years from 1987 to 2011, 876 subjects received 3 primary vaccine doses under 3 studies with 1,537 booster doses administered (FY87-8, phase 2, laboratory workers, vaccine lots 1-81-1, 1-81-2, and 2-1-91; FY99-12, phase 2 laboratory workers, lot 2-1-91; and FY09-02, phase 1 healthy volunteer, lot 3-1-92).

Symptom Characterization and Outcomes of Sailors in Isolation After a COVID-19 Outbreak on a US Aircraft Carrier.

This case series describes the symptoms and outcomes of sailors during and after an outbreak of coronavirus disease 2019 (COVID-19) on the USS Theodore Roosevelt.

Preliminary comparison of vibration measurement accuracy between a low cost, portable acceleration measurement unit and a gold-standard accelerometer system.

Characterization of Whole-Body Vibration (WBV) exposure is important for the development and evaluation of mitigation strategies for occupational WBV. However, barriers associated with cost and complexity limit widespread use of current gold-standard accelerometer (GSA) measurement systems. Small, simple, low cost Acceleration Measurement Unit (AMU) devices with built-in batteries and memory potentially allow for more efficient collection of WBV data, but the measurement accuracy of these devices need to be evaluated.

Author Correction: The emergence of Miocene reefs in South China Sea and its resilient adaptability under varying eustatic, climatic and oceanographic conditions.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

The emergence of Miocene reefs in South China Sea and its resilient adaptability under varying eustatic, climatic and oceanographic conditions.

During the Miocene, extensive carbonate deposition thrived over wide latitudinal ranges in Southeast Asia despite perturbations of the global climate and thermohaline circulation that affected the Asian continent. Nevertheless, the mechanisms of its emergence, adaptability in siliciclastic-dominated margins and demise, especially in southern South China Sea (SCS), are largely speculative and remains enigmatic along with a scarcity of constraints on paleoclimatic and palaeoceanographic conditions. Here we show, through newly acquired high-resolution geophysical data and accurate stratigraphic records based on strontium isotopic dating, the evolution of these platforms from ~15.

Validation of Workflow Changes, Phage Concentration and Reformatted Detection Threshold for the Sample6 DETECT/L™ Test: Level 3 Modification.

The AOAC Research Institute Program certified Sample6 DETECT/L™ in April 2014 (Certification No. 041401) for the detection of species () on stainless steel environmental surfaces. A modification was approved in January 2016, increasing the concentration of sanitizer-neutralizing reagents in detection reagents, increasing the number of phage in the detection solution, and increasing the sample test volume.

NEDD9 stimulated MMP9 secretion is required for invadopodia formation in oral squamous cell carcinoma.

Neural precursor cell expressed developmentally downregulated 9 (NEDD9) is a component of the metastatic signatures of melanoma, breast cancer, glioblastoma, lung cancer and head and neck squamous cell carcinoma (HNSCC). Here we tested the efficacy of NEDD9's domains in stimulating matrix metalloproteinase (MMP) secretion and invadopodia formation in cells stably expressing various NEDD9 mutants. Replacement of the 13 YxxP motif substrate domain (SD) tyrosines and the C-terminal Y629 with phenylalanines (F14NEDD9) eliminated tyrosine phosphorylation, MMP9 secretion and loss of invadopodia formation.

A Comparison of Nonopioid and Opioid Oral Analgesia Following Pediatric Palatoplasty.

Objective: This article evaluates postoperative analgesia in pediatric palatoplasty patients using nonopioid oral medications.

Design: This study was a retrospective chart review.

Setting: The setting for this study was a tertiary-care children's hospital.

The effect of six months of elastic band resistance training, nutritional supplementation or cognitive training on chromosomal damage in institutionalized elderly.

Increased DNA and chromosomal damage are linked to aging and age-related diseases like cardiovascular diseases, diabetes or cancer. Physical activity and an optimal status of micro- and macronutrients are known to reduce the incidence of MN, a marker for chromosomal instability and mutagenicity. Once older people reach a certain age they change from a home-living situation to an institutionalized situation, which is often accompanied by malnutrition, depression and inactivity.

Benchmarking the repeatability of a pneumatic cyclic neutron activation analysis facility using 16O(n,p)16N for nuclear forensics.

A target was prepared for cyclic neutron activation analysis by heat sealing lithium-carbonate in polyethylene. The target was cyclically irradiated 50 times using a Thermo-Scientific accelerator based deuterium-tritium fusion neutron generator. During counting periods, gamma-rays emitted by (16)N were detected using three high-purity germanium detectors acquiring data in list-mode.

Endoscopic Coblation for the treatment of advanced juvenile nasopharyngeal angiofibroma.

We present 2 cases of advanced juvenile nasopharyngeal angiofibroma (JNA) to illustrate the advantages of endoscopic Coblation-assisted resection of intranasal extensions of these masses. Both patients-an 11-year-old boy and a 14-year-old boy-presented with a large, extensive mass (Radkowski stage IIIb and Fisch stage IVb in both cases). After embolization was performed on each patient, his JNA was partially ablated via an endoscopic approach with the Coblator II Surgery System with an EVac Xtra Plasma Wand in conjunction with an image-guided navigation system.

Optimization of rapamycin-loaded acetalated dextran microparticles for immunosuppression.

Immunosuppressive drugs can treat autoimmune disorders and limit rejection with organ transplants. However, delivering immunosuppressants like rapamycin systemically can have harmful side-effects. We aim to potentially reduce these toxic side-effects by encapsulating rapamycin in a polymeric microparticle to passively target phagocytes, the cells integral in immunosuppression.

Complete genome sequence of the filamentous anoxygenic phototrophic bacterium Chloroflexus aurantiacus.

Background: Chloroflexus aurantiacus is a thermophilic filamentous anoxygenic phototrophic (FAP) bacterium, and can grow phototrophically under anaerobic conditions or chemotrophically under aerobic and dark conditions. According to 16S rRNA analysis, Chloroflexi species are the earliest branching bacteria capable of photosynthesis, and Cfl. aurantiacus has been long regarded as a key organism to resolve the obscurity of the origin and early evolution of photosynthesis.

Effect of electrolyte and adsorbates on charging rates in mesoporous gold electrodes.

The classical model for porous electrodes reported by De Levie several decades ago (and expanded upon since then) was developed mainly to describe pores with micrometer-scale diameters. Presumably it will break down as pore diameters approach atomic dimensions. Mesoporous gold formed by dealloying is a valuable test platform for this because its 10 nm pores are on the boundary of this expected breakdown and because the electrochemical and surface properties of gold are relatively well understood.

Supercapacitive transport of pharmacologic agents using nanoporous gold electrodes.

In this study, nanoporous gold supercapacitors were produced by electrochemical dealloying of gold-silver alloy. Scanning electron microscopy and energy dispersive X-ray spectroscopy confirmed completion of the dealloying process and generation of a porous gold material with approximately 10 nm diameter pores. Cyclic voltammetry and chronoamperometry of the nanoporous gold electrodes indicated that these materials exhibited supercapacitor behavior.

Piezoelectric inkjet printing of a cross-hatch immunoassay on a disposable nylon membrane.

The development of a cost-effective method for manufacturing immunoassays is a key step towards their commercial use. In this study, a piezoelectric inkjet printer and a nylon membrane were used to fabricate a disposable immunoassay. Using a piezoelectric inkjet printer, a cross-hatch pattern of goat anti-mouse antibody (GalphaM) and rabbit anti-horseradish peroxidase (RalphaHRP) antibody were deposited on the nylon membrane.