Patterns of Singlehood, Cohabitation, and Marriage in Early Adulthood in Relation to Well-being in Established Adulthood.

In a cohort followed from late adolescence until established adulthood, this study examined how singlehood, cohabitation, and marriage are related to well-being at different ages across early adulthood and into established adulthood.Participants ( = 585) from three U.S.

A Lifecourse Perspective on Singlehood.

A growing number of adults are spending more of their lifetime as single, either because they are taking longer to form unions, are re-entering singlehood after the dissolution of unions, or are avoiding union formation all together. Nevertheless, existing relationship research still generally positions singlehood as something to avoid, limiting our understanding of the rapidly evolving position of singlehood within the lifecourse as well as its implications for health and well-being. Thus, this special issue includes four articles that collectively offer theoretical and empirical inquiries of developmental and historical trends in singlehood and relationship histories, examine the antecedents and consequences of these trends, and explore how they vary based on salient sociodemographic characteristics.

Variability in adolescent reception of parental support: Testing the domain-matching hypothesis.

The present study investigated matches and mismatches between adolescent and parent socialization domains (i.e., protection, guidance) as related to adolescent reception of parental support during a laboratory-based social evaluation challenge.

Kindergarten conduct problems are associated with monetized outcomes in adolescence and adulthood.

Background: Across several sites in the United States, we examined whether kindergarten conduct problems among mostly population-representative samples of children were associated with increased criminal and related (criminal + lost offender productivity + victim; described as criminal + victim hereafter) costs across adolescence and adulthood, as well as government and medical services costs in adulthood.

Methods: Participants (N = 1,339) were from two multisite longitudinal studies: Fast Track (n = 754) and the Child Development Project (n = 585). Parents and teachers reported on kindergarten conduct problems, administrative and national database records yielded indexes of criminal offending, and participants self-reported their government and medical service use.

A Case of Pure Pericarditis Associated With COVID-19: Application of Classical Clinical Evaluation for Differential Diagnosis.

Pericarditis of varying severity is being recognized as a rare complication of the COVID-19 infection. We present a patient with an electrocardiogram (EKG) and physical exam findings that initially seemed to most likely be pericarditis related to the COVID-19 infection. The differential diagnosis was a bit difficult because it included ST-segment elevation myocardial infarction (STEMI) due to some EKG changes and early repolarization changes that were rather robust.

Parental sensitivity predicts parent-adolescent agreement about peer victimization.

Effective parental responses to peer victimization may hinge on parental awareness of youths' peer victimization experiences, yet predictors of parental awareness are understudied. We investigated the extent of parent-adolescent agreement about early adolescents' peer victimization experiences as well as predictors of parent-adolescent agreement. Participants included a diverse community sample of early adolescents ( = 80; = 12.

Externalizing psychopathology from childhood to early adolescence: Psychometric evaluation using latent variable and network modeling.

Applying both latent variable and network frameworks, we conducted a comprehensive psychometric evaluation of the diverse array of symptoms from three externalizing dimensions, including attention problems, aggressive behavior, and delinquency/rule-breaking of the Child Behavior Checklist (Achenbach, 1991) across six time points from childhood to early adolescence. We also examined sex differences. Participants ( = 1,339) were drawn from two multisite longitudinal studies: Fast Track and the Child Development Project.

Predictors of problematic adult alcohol, cannabis, and other substance use: A longitudinal study of two samples.

This study examined whether a key set of adolescent and early adulthood risk factors predicts problematic alcohol, cannabis, and other substance use in established adulthood. Two independent samples from the Child Development Project (CDP; = 585; 48% girls; 81% White, 17% Black, 2% other race/ethnicity) and Fast Track (FT; = 463; 45% girls; 52% White, 43% Black, 5% other race/ethnicity) were recruited in childhood and followed through age 34 (CDP) or 32 (FT). Predictors of substance use were assessed in adolescence based on adolescent and parent reports and in early adulthood based on adult self-reports.

The interaction of spongistatin 1 with tubulin.

A tritiated derivative of the sponge-derived natural product spongistatin 1 was prepared, and its interactions with tubulin were examined. [H]Spongistatin 1 was found to bind rapidly to tubulin at a single site (the low specific activity of the [H]spongistatin 1, 0.75 Ci/mmol, prevented our defining an association rate), and the inability of spongistatin 1 to cause an aberrant assembly reaction was confirmed.

A defensive mindset: A pattern of social information processing that develops early and predicts life course outcomes.

The hypothesis was tested that some children develop a defensive mindset that subsumes individual social information processing (SIP) steps, grows from early experiences, and guides long-term outcomes. In Study 1 (Fast Track [FT]), 463 age-5 children (45% girls; 43% Black) were first assessed in 1991 and followed through age 32 (83% retention). In Study 2 (Child Development Project [CDP]), 585 age-5 children (48% girls, 17% Black) were first assessed in 1987 and followed through age 34 (78% retention).

Predictive Validity of Adolescent Callous-Unemotional Traits and Conduct Problems with Respect to Adult Outcomes: High- and Low-Risk Samples.

Current understanding of the predictive validity of callous-unemotional (CU) traits is limited by (a) the focus on externalizing psychopathology and antisocial behaviors, (b) a lack of long-term prospective longitudinal data, (c) samples comprised of high-risk or low-risk individuals. We tested whether adolescent CU traits and conduct problems were associated with theoretically relevant adult outcomes 12-18 years later. Participants were drawn from two studies: higher-risk Fast Track (FT; n = 754) and lower-risk Child Development Project (CDP; n = 585).

Refractive Outcomes after Cataract Surgery.

A post-operative manifest refractive error as close as possible to target is key when performing cataract surgery with intraocular lens (IOL) implantation, given that residual astigmatism and refractive errors negatively impact patients' vision and satisfaction. This review explores refractive outcomes prior to modern biometry; advances in biometry and its impact on patients' vision and refractive outcomes after cataract surgery; key factors that affect prediction accuracy; and residual refractive errors and the impact on visual outcomes. There are numerous pre-, intra-, and post-operative factors that can influence refractive outcomes after cataract surgery, leaving surgeons with a small "error budget" (i.

The destabilization and destandardization of social roles across the adult life course: Considering aggregate social role instability and its variability from a historical-developmental perspective.

Existing research focused on social role destabilization (historical increases in role instability) and destandardization (historical increases in variability of role instability) has primarily focused on discrete social roles during discrete periods of development. Building on this work, we applied a macro approach to elucidate the extent to which historical trends toward destabilization and destandardization are occurring at the aggregate among a key set of social roles (union formation, education, residential independence, and employment) and across the whole of adulthood. Applying a historical-developmental approach, we also document how historical trends toward destabilization and destandardization vary by age.

Impact of the COVID-19 pandemic on substance use among adults without children, parents, and adolescents.

Impact of the COVID-19 pandemic on alcohol and illicit substance use among adults without children, parents, and adolescents was investigated through two studies with five samples from independent ongoing U.S. longitudinal studies.

Coping with Relationship Stress in Adolescence: A Decade in Review.

At a moment in history when stress levels among adolescents are high and coping capacities are taxed, it seems timely and important to review a decade's accomplishments in elucidating how, and with what effects, adolescents cope with relationship stress. We provide an update on research about coping with parent, peer, and romantic stress and discuss the effectiveness of coping strategies across cultures, developmental periods, and levels of social stress. We explore relations between coping and other automatic and reflective responses to stress and highlight innovations in lab-based and ambulatory assessments.

Organized Activity Involvement Predicts Internalizing and Externalizing Problems in Adolescence.

Despite the expected benefits of organized activity involvement (e.g., sports, clubs), inconsistencies in associations between activity involvement and internalizing and externalizing problems may be explained in part by limitations of measurements and variations between individuals.

Development of individuals' own and perceptions of peers' substance use from early adolescence to adulthood.

This study evaluated how individuals' own substance use and their perception of peers' substance use predict each other across development from early adolescence to middle adulthood. Participants were from two longitudinal studies: Fast Track (FT; N = 463) and Child Development Project (CDP; N = 585). Participants reported on their own and peers' substance use during early and middle adolescence and early adulthood, and their own substance use in middle adulthood.

Early Physical Abuse and Adult Outcomes.

Background: Because most physical abuse goes unreported and researchers largely rely on retrospective reports of childhood abuse or prospective samples with substantiated maltreatment, long-term outcomes of physical abuse in US community samples are unknown. We hypothesized that early childhood physical abuse would prospectively predict adult outcomes in education and economic stability, physical health, mental health, substance use, and criminal behavior.

Methods: Researchers in two multisite studies recruited children at kindergarten entry and followed them into adulthood.

Individual and Environmental Predictors of Age of First Intercourse and Number of Children by Age 27.

Reproductive behavior characteristics may be influenced by both social and individual factors. Recent studies have revealed that personality traits might be related to reproductive characteristics in adulthood. Little is known about potential mediators or moderators of relations between personality and reproductive behavior.

Adolescent social withdrawal, parental psychological control, and parental knowledge across seven years: A developmental cascade model.

Introduction: Social withdrawal can be problematic for adolescents, increasing the risk of poor self-efficacy, self-esteem, and academic achievement, and increased levels of depression and anxiety. This prospective study follows students across adolescence, investigating links between social withdrawal and two types of parenting hypothesized to impact or be reactive to changes in social withdrawal.

Methods: Adolescent social withdrawal and parenting were assessed across seven years in a U.

Antineoplastic Agents. 607. Emetine Auristatins.

The remarkable biological activity of the dolastatin 10 structural modifications quinstatins and isoquinstatins prompted further investigation into drug hybrids containing biologically active isoquinoline moieties. In this study, the isoquinoline alkaloid emetine was selected as one of the structural domains of a hybrid molecule. That was accomplished by covalently bonding the Dov-Val-Dil-Dap peptide sequence of dolastatin 10 peptide at the N-2' secondary amine of emetine.

Cumulative early childhood adversity and later antisocial behavior: The mediating role of passive avoidance.

Twenty-six percent of children experience a traumatic event by the age of 4. Negative events during childhood have deleterious correlates later in life, including antisocial behavior. However, the mechanisms that play into this relation are unclear.

Interaction of diazonamide A with tubulin.

[H]Diazonamide A ([H]DZA), prepared from the natural product isolated from Diazona angulata, bound to tubulin in larger aberrant assembly products (>500 kDa by sizing HPLC) but not to the αβ-tubulin heterodimer. The binding reaction was rapid, but stoichiometry was low. Stoichiometry was enhanced up to 8-fold by preincubating the tubulin in the reaction mixture prior to adding the [H]DZA.