GENA-LM: a family of open-source foundational DNA language models for long sequences.

Recent advancements in genomics, propelled by artificial intelligence, have unlocked unprecedented capabilities in interpreting genomic sequences, mitigating the need for exhaustive experimental analysis of complex, intertwined molecular processes inherent in DNA function. A significant challenge, however, resides in accurately decoding genomic sequences, which inherently involves comprehending rich contextual information dispersed across thousands of nucleotides. To address this need, we introduce GENA language model (GENA-LM), a suite of transformer-based foundational DNA language models capable of handling input lengths up to 36 000 base pairs.

Detection of Human Bladder Epithelial Cancerous Cells with Atomic Force Microscopy and Machine Learning.

The development of noninvasive methods for bladder cancer identification remains a critical clinical need. Recent studies have shown that atomic force microscopy (AFM), combined with pattern recognition machine learning, can detect bladder cancer by analyzing cells extracted from urine. However, these promising findings were limited by a relatively small patient cohort, resulting in modest statistical significance.

Boosting the performance of a zero-gap flow microbial fuel cell by immobilized redox mediators.

Although microbial fuel cells (MFC) could be a promising energy source, their implementation is largely limited by low performance. There are several approaches to overcome this issue. For example, MFC performance can be enhanced using redox mediators (RM) capable of transferring electrons between microorganisms and MFC electrodes.

Photo-thermo-optical modulation of Raman scattering from Mie-resonant silicon nanostructures.

Raman scattering is sensitive to local temperature and thus offers a convenient tool for non-contact and non-destructive optical thermometry at the nanoscale. In turn, all-dielectric nanostructures, such as silicon particles, exhibit strongly enhanced photothermal heating due to Mie resonances, which leads to the strong modulation of elastic Rayleigh scattering intensity through subsequent thermo-optical effects. However, the influence of the complex photo-thermo-optical effect on inelastic Raman scattering has yet to be explored for resonant dielectric nanostructures.

Strongly subradiant states in planar atomic arrays.

The optically trapped ensembles of atoms provide a versatile platform for storing and coherent manipulation of quantum information. However, efficient realization of quantum information processing requires long-lived quantum states protected from the decoherence e.g.

The moderating effect of cardiometabolic factors on the association between hepatic and intrapancreatic fat.

Objective: Previous studies have investigated the association between hepatic fat and intrapancreatic fat deposition (IPFD); however, results have been inconclusive. The presence of cardiometabolic factors in certain subpopulations could explain this discrepancy. The aim of the present study was to use moderation analyses to determine the conditions under which hepatic fat is associated with IPFD.

The Presence of Bilateral Dilated Pupils is Not a Death Sentence in a Stroke Patient: A Case Report.

Bilateral dilated pupils are an ominous clinical sign of brainstem dysfunction, which uniformly leads to a bad prognosis for the patient. In some rare instances in adult patients, it could be reversible. We present a clinical case of an elderly stroke patient with bilateral dilated pupils with a surprisingly favorable clinical outcome.

Relationship of high-density lipoprotein subfractions and apolipoprotein A-I with fat in the pancreas.

Aim: To investigate the associations of high-density lipoprotein (HDL) subfractions and apolipoprotein A-I (apo A-I) with fat in the pancreas.

Methods: A total of 170 individuals were studied. All participants underwent magnetic resonance imaging on a single 3.

Second-Order Nonlinear Circular Dichroism in Square Lattice Array of Germanium Nanohelices.

Second-harmonic generation (SHG) is prohibited in centrosymmetric crystals such as silicon or germanium due to the presence of inversion symmetry. However, the structuring of such materials makes it possible to break the inversion symmetry, thus achieving generation of second-harmonic. Moreover, various symmetry properties of the resulting structure, such as chirality, also influence the SHG.

Water quality and dissolved load in the Chirchik and Akhangaran river basins (Uzbekistan, Central Asia).

Uzbekistan (Central Asia) is experiencing serious water stress as a consequence of altered climate regime, past over-exploitation, and dependence from neighboring countries for water supply. The Chirchik-Akhangaran drainage basin, in the Tashkent province of Uzbekistan, includes watersheds from the Middle Tien Shan Mountains escarpments and the downstream floodplain of the Chirchik and Akhangaran rivers, major tributaries of the Syrdarya river. Water in the Chirchik-Akhangaran basin is facing potential anthropogenic pressure from different sources at the scale of river reaches, from both industrial and agricultural activities.

Epidemiology of post-pancreatitis diabetes mellitus: insights from the COSMOS program.

Introduction: Post-pancreatitis diabetes mellitus (PPDM) has long been recognized as one of the most challenging sub-types of diabetes to manage. Part of the problem is that the earlier literature on epidemiology of PPDM was confusing because of the presence of selection bias.

Areas Covered: A concerted series of population-based nationwide studies on PPDM from New Zealand has recently been published as part of the COSMOS (Clinical and epidemiOlogical inveStigations in Metabolism, nutritiOn, and pancreatic diseaseS) program and is the main focus of the present article.

Effect of Acute Nutritional Ketosis on Circulating Levels of Growth Differentiation Factor 15: Findings from a Cross-Over Randomised Controlled Trial.

Exogenous supplementation with ketone beverages has been shown to reduce plasma glucose levels during acute nutritional ketosis. It remains to be investigated whether growth differentiation factor 15 (GDF-15)-an anorexigenic hormone-is involved in this process. The aim was to investigate the effect of a ketone ester beverage delivering β-hydroxybutyrate (KEβHB) on plasma levels of GDF-15, as well as assess the influence of eating behaviour on it.

Response to lowering plasma glucose is characterised by decreased oxyntomodulin: Results from a randomised controlled trial.

Background: With the prevalence of diabetes reaching an epidemic level, there is a growing interest in the investigation of its remission. Proglucagon-derived peptides (PGDP) have been shown to have a glucose-regulating effect. However, whether they play a role in diabetes remission remains poorly understood.

Stochastic circular persistent currents of exciton polaritons.

We monitor the orbital degree of freedom of exciton-polariton condensates confined within an optical trap and unveil the stochastic switching of persistent annular polariton currents under pulse-periodic excitation. Within an elliptical trap, the low-lying in energy polariton current states manifest as a two-petaled density distribution with a swirling phase. In the stochastic regime, the density distribution, averaged over multiple excitation pulses, becomes homogenized in the azimuthal direction.

Cryosphere and land cover influence on stream water quality in Central Asia's glacierized catchments.

This work helps address recent calls for systematic water quality assessment in Central Asia and considers how nutrient and salinity sources, and transport, affect water quality along the continuum from the cryosphere to the lowland plains. Spatial and, for the first time, temporal variations in stream water pH, temperature, electrical conductivity, and nitrate and phosphate concentrations are presented for four catchments (485-13,500 km), all with glaciers and major urban areas. The catchments studied were: Kaskelen (Kazakhstan), Ala-Archa (Kyrgyzstan), Chirchik (Uzbekistan) and the Kofarnihon (Tajikistan).

3U CubeSat-Based Hyperspectral Remote Sensing by Offner Imaging Hyperspectrometer with Radially-Fastened Primary Elements.

This paper presents findings from a spaceborne Earth observation experiment utilizing a novel, ultra-compact hyperspectral imaging camera aboard a 3U CubeSat. Leveraging the Offner optical scheme, the camera's hyperspectrometer captures hyperspectral images of terrestrial regions with a 200 m spatial resolution and 12 nanometer spectral resolution across a 400 to 1000 nanometer wavelength range, covering 150 channels in the visible and near-infrared spectrums. The hyperspectrometer is specifically designed for deployment on a 3U CubeSat nanosatellite platform, featuring a robust all-metal cylindrical body of the hyperspectrometer, and a coaxial arrangement of the optical elements ensures optimal compactness and vibration stability.

Biobehavior Life Regulation (BLR) scale for living well in chronic pain: Preliminary scale development and validation.

Currently available pain assessment scales focus on pain-related symptoms and limitations imposed by pain. Validated assessment tools that measure how pain is regulated by those who live well with pain are missing. This study seeks to fill this gap by describing the development and preliminary validation of the Biobehavior Life Regulation (BLR) scale.

[Thyroid cartilage fracture following sneezing as a cause of spontaneous pneumomediastinum].

Objective: To evaluate the possible etiological factors of spontaneous pneumomediastinum and to describe a case that was unusual in its etiology: a thyroid cartilage fracture as a result of sneezing.

Material And Methods: Six patients (four male, two female, aged 16-82 years) were hospitalized with spontaneous pneumomediastinum diagnosed with a chest X-ray in five patients and 100% with computed tomography. Treatment was symptomatic.

The Pharmacological Landscape for Fatty Change of the Pancreas.

The quest for medications to reduce intra-pancreatic fat deposition is now quarter a century old. While no specific medication has been approved for the treatment of fatty change of the pancreas, drug repurposing shows promise in reducing the burden of the most common disorder of the pancreas. This leading article outlines the 12 classes of medications that have been investigated to date with a view to reducing intra-pancreatic fat deposition.

Associations of Infant Feeding, Sleep, and Weight Gain with the Toddler Gut Microbiome.

This study examines how feeding, sleep, and growth during infancy impact the gut microbiome (GM) in toddlers. The research was conducted on toddlers ( = 36), born to Latina women of low-income with obesity. Their mothers completed retrospective feeding and sleeping questionnaires at 1, 6, and 12 months; at 36 months, fecal samples were collected.