[Injuries of the menisci in patients with deforming gonarthrosis].

The authors present their observations concerning the difficulties in the diagnosis of the injuries of the menisci of the knee joint associated with deforming arthrosis which have quite a number of similar clinical signs with injuries of the menisci. The importance of an arthroscopic study of the meniscus of the knee joint is demonstrated for revealing the lesion as well as a possibility of solution to the problem of partial meniscectomy. The expediency of such tactics is confirmed by the results of the treatment of 28 patients, in 10 of whom lesions of the inner menisci were revealed and partial meniscectomies were performed.

[Effect of bonafton on the formation of specific suppressor cells].

Administration of an antiviral agent bonafton (1.5 mg/kg, intraperitoneally) for 5 days to mice immunized with a supraoptimal dose of ram erythrocytes (5 X 10(9)) was followed by inhibition of suppressor-cell induction in the animal spleen. An adoptive transfer of the splenic cells of these mice to syngeneic recipients caused in the latter less specific inhibition of humoral and cellular immune responses than it was during the use of splenocytes from hyperimmunized donor mice not receiving bonafton.

[Immunostimulating effects in the body induced by bonafton].

Study of the primary immune response in CBA mice which were injected with bonafton (1.5-3 mg/kg i.p.

[Electron microscopic studies of experimental staphylococcal infections in mice as chemotherapeutic models].

Study of ultrastructural changes in the brain and renal tissues has shown that both intracerebral and intraperitoneal administration of staphylococcus in low infecting doses leads to the development in the brain and renal tissues of acute purulent inflammation, with a dramatic growth of infectious process and involvement of all parts of the organs under consideration. The presence in the brain tissues and in its meninges of inflammatory pyonecrotic foci might attest to the necrotic purulent encephalomeningitis, whereas the presence in the cortex and renal medullary substance of histiolymphocytic infiltration and foci of necrosis might be evidence of necrotic glomerulonephritis of bacterial etiology.

[Activity of di-N-hydroxyquinoxaline and depot-sulfanilamide derivatives in experimental NAG infection].

In experiments in vitro dioxidineeee was highly effective as regards all the test cultures of NAG-vibrios. The MTC ranged within 1 to 62 micrograms/ml. Bactericidal action of the drug became manifest at concentrations from 4 to 250 micrograms/ml.

[Effect of riodoxol on herpes simplex virus morphogenesis in experimental eye infection].

The effect of riodoxol on herpes simplex type 1 viruses was studied. It was shown to affect multiplication and maturation of the virus as manifested in the appearance of virions with incomplete nucleoid structure and long-term presence of virions in cytoplasmic vacuoles in cells. Submicroscopic changes suggest a dual effect of riodoxol on herpes simplex virus: on the DNA replicative cycle and on the stage of late maturation of virus at the time of its release from the nucleus.

[Pharmacokinetics and antiviral activity of riodoksol in an ointment and in ophthalmic drug films in ocular herpes].

A study was made on the pharmacokinetics in rabbit eye tissues of a new antiviral drug riodoksol in the form of ointment and biosoluble eye films. The pharmacokinetics of the drug was studied in eye tissues of normal rabbits and in those infected with herpes simplex virus. It was disclosed that four-fold application of 0.

[Effect of dioxidine on DNA and RNA synthesis in Staphylococcus aureus].

The effect of dioxidin on DNA and RNA synthesis by Staphylococcus aureus was studied with the use of labeled precursors and evaluated from the kinetics of DNA and RNA accumulation by the culture. It was shown that dioxidin inhibits DNA synthesis by Staphylococcus aureus cells, with the synthesis of RNA being almost not affected. The main effect manifests within the first hour of the drug interplay with the microbial cell, it is reversible and appears to be realized by the mechanisms of DNA synthesis regulation.

[Electron microscopic study of the antiviral action of bonafton in experimental influenza infection].

Action of bonaphthon on influenza A virus was studied in experimental influenzal pneumonia of mice. Bonaphthon was shown to lower 1.5-2 fold the reproduction of influenza virus in pulmonary tissue as compared with control.

[Basic trends and the prospects for creating new synthetic chemotherapeutic preparations].

Chemotherapy and chemoprophylaxis play a significant role in control of various infectious diseases. The use of chemotherapeutic drugs is associated with a number of difficulties, such as development of drug resistance in pathogenic microorganism during the treatment, possible toxic effects of drugs on their prolonged use, inefficiency of chemotherapy in bacteria carriers, etc. In spite of the achievements in chemotherapy of acute bacterial infections, tuberculosis, lepra, mycoses, protozoal infections, it is necessary to have available new drugs for the treatment of these diseases.

[Mechanism of the antiherpetic action of bonafton].

The mechanism of antiherpetic action of bonaphthon was studied in experimental herpetic keratitis of rabbits infected with herpes simplex type I virus (Koptev and IC strains). Electron microscopy demonstrated that the drug inhibits herpes virus production and proliferation of virus infection because of partial impairment of the nucleocapsid "assembly" in the cell nucleus. It is assumed that the action of bonaphthon may be consequent on the inhibition of the cell synthesis of cytoplasmatic proteins incorporated into the capsids and on the derangement of the transport of virus capsid components to the cell nucleus, where these components are assembled.

[Rat postnatal development after bonafton exposure].

The first generation progeny of rats received days 10-13 of pregnancy a new antiviral drug bonaphthon (400 mg/kg) which exerts a toxic effect on females. The progeny did not show postnatal death or reduction of the life span. Moreover, no impairment of muscle work capacity, basal metabolism, cardiovascular system, peripheral blood parameters, or changes in the function of organs and systems were recorded.

[Pyrrolo(3,2-d)pyrimidines as potential antitumor agents].

Antibacterial and antitumor properties of pyrrolo (3,2-d) pyrimidines having diverse substituents in the second, fourth and sixth position were investigated. Forty-four compounds were examined in vitro and 20 in vivo. A number of the derivatives were shown to inhibit the growth of M.

[Effect of quinolaline di-N-oxide derivatives on the DNAse and plasmocoagulase of Staphylococcus aureus].

The effect of the di-N-oxide quinoxaline on the activity and biosynthesis of DNA-ase and plasmocoagulating properties of the Staphylococcus aureus, strain Zhaev, was studied. The highest action in respect to DNA-ase of the Staphylococcus is shown to display dioxydine (1,4-di-N-oxide of 2,3-dioxymethylquinoxaline). Under its effect there takes place a significant fall of the DNA-ase activity and the plasmocoagulating properties of the staphylococcus.

[Effect of bonaphthone on embryogenesis in white rats and mice].

Results of testing the embryotropic activity of bonaphthone used in different doses (700; 400; 100; 50 and 2 mg/kg) are reported. With its oral introduction to pregnant rats bonaphthone, given in doses at the level of the therapeutid one (2 mg/kg) and exceeding it by as much as 25 times (50 mg/kg), was found not to produce any damaging effect on the fetus. With its action in doses of 100 and 400 mg/kg a slight embryotoxic effect was noted.

[Urinary excretion of dioxidine and quinoxidine in experiments on mice].

By using spectrochromatography the dioxidine and quinoxidine passage with urine, depending upon their doses and the method of introduction, was studied in tests on mice. On its enteral or subcutaneous introduction dioxidine is found in the urine within a period of 7-to 24 hours (depending upon the dose administered). With its maximum concentration it is definable within 1 hour.