The Efficacy of Anlotinib Plus Whole Brain Radiotherapy in Advanced Non-Small Cell Lung Cancer With Multiple Brain Metastases: A Retrospective Study.

Purpose: This study aimed to compare the efficacy of anlotinib plus whole-brain radiotherapy (WBRT) with that of WBRT alone in non-small cell lung cancer (NSCLC) patients with multiple brain metastases (BMs).

Methods: The clinical data of patients with NSCLC and multiple BMs who received WBRT between 2019 and 2022 were collected. The patients were assigned to anlotinib plus WBRT group and WBRT group according to the treatment used.

The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation.

Background And Objective: Chronic prostatitis (CP) is a condition markered by persistent prostate inflammation, yet the specific cytokines driving its progression remain largely undefined. This study aims to identify key cytokines involved in CP and investigate their role in driving inflammatory responses through mechanistic and therapeutic exploration.

Methods: A 48-cytokine panel test was conducted to compare the plasma cytokine profiles between participants with CP-like symptoms (CP-LS) and healthy controls.

A systematic comparative analysis of gait characteristics in patients undergoing total knee arthroplasty and unicompartmental knee arthroplasty: a review study.

Background: This study systematically reviews recent research comparing clinical outcomes and gait function changes in patients undergoing total knee arthroplasty (TKA) versus unicompartmental knee arthroplasty (UKA).

Methods: A systematic search of the Web of Science, PubMed, and Embase databases was conducted, covering publications from January 2013 to September 2024, to identify studies evaluating changes in clinical scores and gait parameters in patients undergoing TKA or UKA. Following stringent selection criteria, data were synthesized from studies involving 171 TKA and 148 UKA patients, focusing on reported gait outcomes and aggregating findings for comprehensive analysis.

Development and evaluation of spirometry reference equations at high altitude.

Approximately 400 million people live at high altitudes worldwide, yet reference equations for spirometry in these populations are inadequately documented. This study aims to develop reference equations for spirometry and assess their applicability to residents at altitudes ranging from 2,100 to 4,700 metres above sea level. This extensive cross-sectional study encompassed healthy non-smokers aged 15 years or older living at Xinjiang and Tibet autonomous region, which covered eight high-altitude areas by a multistage stratified sampling procedure.

Transformation of Arsenic from Poison into Active Site by Construction of Unique AsO/CeO Interface for Stable NO Removal.

Arsenic in the flue gas has been widely reported as a common poison for SCR catalysts; however, an appropriate coping strategy is still lacking to improve the arsenic resistance performance. Herein, a unique AsO/CeO interface is constructed to transform arsenic from poison into active site with balanced acid-redox property, successfully achieving efficient NO removal. The optimized AsO/CeO exhibits high NO removal efficiency, four times that of the As-poisoned VO/TiO catalyst, and even comparable to the state-of-the-art SCR catalysts.

Spin-symmetry-enforced solution of the many-body Schrödinger equation with a deep neural network.

The integration of deep neural networks with the variational Monte Carlo (VMC) method has marked a substantial advancement in solving the Schrödinger equation. In this work we enforce spin symmetry in the neural-network-based VMC calculation using a modified optimization target. Our method is designed to solve for the ground state and multiple excited states with target spin symmetry at a low computational cost.

Islet-derived exosomal miR-204 accelerates insulin resistance in skeletal muscle by suppressing sirtuin 1: An in vivo study in a mouse model of high-fat diet-induced obesity.

Aims: The interaction between pancreatic islets and skeletal muscle plays a pivotal role in the development of insulin resistance. The present study aimed to elucidate the impact of non-hormonal molecules from islets on the insulin sensitivity of skeletal muscle cells.

Materials And Methods: We developed a mouse model of obesity through a high-fat diet, assessing glucose tolerance and conducting miRNA sequencing on skeletal muscle samples.

Chlorophyll-Inspired Magnesium Porphyrin Array Membrane for Vis-Light-Enhanced Osmotic Energy Conversion.

Osmotic energy, a renewable clean energy, can be directly converted into electricity through ion-selective membranes. Inspired by the magnesium porphyrin (Mg) in plant chlorophyll, which absorbs vis-light and promotes photoelectric conversion, we demonstrate a Mg array membrane, realizing vis-light-enhanced ion transport regulation ability and osmotic energy conversion. The Mg arrays are self-assembled by a Mg-cored block copolymer under the coordination effect of block copolymer self-assembly and Mg π-π stacking, providing chloride-selective transport channels.

Type I Porous Liquids with Super-Low Viscosities: the Construction through a Rather Simple One-Step Covalent Linkage Strategy and Its Facile Regulation by a Mixed-Ligand Strategy.

Porous liquids (PLs) are a novel class of flowing liquid systems that possess accessible permanent porosity, exhibiting great prospects in gas capture and separation. Nevertheless, the further development of PLs lies in the facile synthesis and regulation of PLs with low viscosities. Herein, a novel strategy of preparing type I PLs with super-low viscosity is proposed through a simple one-step covalent linkage reaction using UiO-66-NH as the pore generator and monoglycidyl ether terminated polydimethylsiloxane (E-PDMS) as the sterically hindered solvent, respectively.

Phase Engineering of Giant Second Harmonic Generation in BiOSe.

2D materials with remarkable second-harmonic generation (SHG) hold promise for future on-chip nonlinear optics. Relevant materials with both giant SHG response and environmental stability are long-sought targets. Here, the enormous SHG from the phase engineering of a high-performance semiconductor, BiOSe (BOS), under uniaxial strain, is demonstrated.

Nanoformula Design for Inducing Non-Apoptotic Cell Death Regulation: A Powerful Booster for Cancer Immunotherapy.

Cancer treatment has witnessed revolutionary advancements marked by the emergence of immunotherapy, specifically immune checkpoint blockade (ICB). However, the inherent low immunogenicity of tumor cells and the intricate immunosuppressive network within the tumor microenvironment (TME) pose significant challenges to the further development of immunotherapy. Nanotechnology has ushered in unprecedented opportunities and vast prospects for tumor immunotherapy.

Biomimetic Metallacage Nanoparticles with Aggregation-Induced Emission for NIR-II Fluorescence Imaging-Guided Synergistic Immuno-Phototherapy of Tumors.

The integration of theranostics, which combines diagnostics with therapeutics, has markedly improved the early detection of diseases, precise medication management, and assessment of treatment outcomes. In the realm of oncology, organoplatinum-based supramolecular coordination complexes (SCCs) that can coload therapeutic agents and imaging molecules have emerged as promising candidates for multimodal theranostics of tumors. To address the challenges of tumor-targeted delivery and multimodal theranostics for SCCs, this study employs a cell membrane cloaking strategy to fabricate biomimetic metallacage nanoparticles (MCNPs) with multimodal imaging capabilities and homologous targeting capabilities.

Optimization and Biological Evaluation of Novel 1-Pyrrolo[2,3-]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia.

Lysine-specific demethylase 1 (LSD1) plays a vital role in the epigenetic regulation of various cancers, making it a promising therapeutic target for anticancer treatments. Herein, we designed and synthesized a novel series of 1-pyrrolo[2,3-]pyridin derivatives as potent LSD1 inhibitors. A detailed structure-activity relationship exploration was carried out to discover multiple derivatives with nanomolar enzymatic IC values.

Rational Design of Porous YO-MnO/Carbon Heterostructures with Abundant Oxygen Vacancies for High-Efficiency and Ultrastable Zinc-Ion Storage.

Manganese oxides have been considered as the most competitive cathode materials for aqueous zinc-ion batteries (ZIBs) on account of their inherent safety, high operating voltage, environmental friendliness, and cost-effectiveness. Unfortunately, the manganese dissolution, inherently poor electronic conductivity, and the sluggish reaction kinetics of commercial manganese-based oxides severely hinder their practical applications. To address the above issues, we creatively developed hierarchical porous YO-MnO/C nanorods (named O-YMO/C) with unique heterostructures and abundant oxygen vacancies via a facile MOF-assisted synthetic process and employed as the advanced cathode.

Metal-Organic Coordination Enhanced Metallopolymer Electrolytes for Wide-Temperature Solid-State Lithium Metal Batteries.

The practical application of polymer electrolytes is seriously hindered by the inferior Li ionic conductivity, low Li transference number (t), and poor interfacial stability. Herein, a structurally novel metallopolymer is designed and synthesized by exploiting a molybdenum (Mo) paddle-wheel complex as a tetratopic linker to bridge organic and inorganic moieties at molecular level. The prepared metallopolymer possesses combined merits of outstanding mechanical and thermal stability, as well as a low glass transition temperature (T <-50 °C).

Performance enhancement of mid-infrared NH sensor using 9.06 μm QCL based on spectral optimization and NGO-LSTM model.

A detection sensor for mid-infrared ammonia (NH) has been developed according to wavelength modulation spectroscopy-tunable diode laser absorption spectroscopy (WMS-TDLAS) technology, which can be applied in the chemical and aquaculture industries. A 9.06 µm quantum cascade laser (QCL) and a 41.

Effect of Lanthanum-Aluminum Co-Doping on Structure of Hafnium Oxide Ferroelectric Crystals.

Hafnium oxide (HfO)-based devices have been extensively evaluated for high-speed and low-power memory applications. Here, the influence of aluminum (Al) and lanthanum (La) co-doping HfO thin films on the ferroelectric characteristics of hafnium-based devices is investigated. Among devices with different La/Al ratios, the Al and La co-doped hafnium oxide (HfAlAO) device with 4.

Single-Cell Simultaneous Metabolome and Transcriptome Profiling Revealing Metabolite-Gene Correlation Network.

Metabolic studies at the single cell level can directly define the cellular phenotype closest to physiological or disease states. However, the current single cell metabolome (SCM) study using mass spectroscopy has difficulty giving a complete view of the metabolic activity in the cell, and the prediction of the metabolism-phenotype relationship is limited by the potential inconsistency between transcriptomic and metabolic levels. Here, the single-cell simultaneous metabolome and transcriptome profiling method (scMeT-seq) is developed at one single cell, based on sub-picoliter sampling from the cell for the initial metabolome profiling followed by single cell transcriptome sequencing.

A Multimode Optical Sensor for Highly Selective and Sensitive Detection of Hypochlorous Acid in Water and Body Fluid.

Hypochlorous acid (HClO), as an important reactive oxygen species (ROS), plays a crucial role in our daily life and in biological systems, and its convenient and accurate detection is significant and imperative. In this work, a self-calibrated multimode optical sensor for convenient and accurate HClO detection was elaborately fabricated based on a multifunctional metal-organic framework platform with catalytic active metal nodes, fluorescent responsive bridging ligands, and intrinsic pores for functional molecule accommodation. The sensor shows not only turn-on and ratiometric fluorescence response but also color change in response to HClO.

Recent advances in the organocatalytic synthesis of chiral C3-spiro-cyclopentaneoxindoles.

Although there have been various reviews on the asymmetric construction of C3-spirooxindoles, there is a scarcity of reviews focusing on the asymmetric organocatalytic synthesis of C3-spiro-cyclopentaneoxindole derivatives. This particular scaffold has garnered significant attention from synthetic chemists due to its relevance in medicinal chemistry. In this review, we provide an overview of recent advancements in the asymmetric organocatalytic synthesis of various C3-spiro-cyclopentaneoxindoles using organic catalysts.