Publications by authors named "P-M Mertes"
Objective: To describe neuroimaging findings and to report the epidemiologic and clinical characteristics of patients with coronavirus disease 2019 (COVID-19) with neurologic manifestations.
Methods: In this retrospective multicenter study (11 hospitals), we included 64 patients with confirmed COVID-19 with neurologic manifestations who underwent a brain MRI.
Results: The cohort included 43 men (67%) and 21 women (33%); their median age was 66 (range 20-92) years.
Article Synopsis
- Background: The study examines brain MRI abnormalities in patients with severe COVID-19 (SARS-CoV-2) and identifies potential neurological issues related to the virus.
- Methods: Researchers analyzed data from 37 hospitalized patients who had neurological symptoms and abnormal brain MRIs between March and April 2020, excluding cases with ischemic strokes or unrelated chronic lesions.
- Results: The patient cohort, primarily older men, exhibited various neurological symptoms, with MRI findings showing significant abnormalities in brain regions including the medial temporal lobe and evidence of microhemorrhages, suggesting COVID-19's impact on brain structure.
Background: Grading schemes for severity of suspected allergic reactions have been applied to the perioperative setting, but there is no scoring system that estimates the likelihood that the reaction is an immediate hypersensitivity reaction. Such a score would be useful in evaluating current and proposed tests for the diagnosis of suspected perioperative immediate hypersensitivity reactions and culprit agents.
Methods: We conducted a Delphi consensus process involving a panel of 25 international multidisciplinary experts in suspected perioperative allergy.
Article Synopsis
- The study investigates the differences in plasma histamine and tryptase levels in patients experiencing severe allergic reactions during anesthesia compared to those in shock from other causes.
- Researchers analyzed data from patients with confirmed allergies to administered agents and compared their mediator concentrations to patients suffering from septic or cardiogenic shock during resuscitation efforts.
- Results showed significantly higher histamine and tryptase levels in the allergy group, with established thresholds that could help distinguish allergic reactions from other conditions, which is important for understanding causes of death during anesthesia.
Vitamin A deficiency is associated with increased susceptibility to infection but the effects of Vitamin A supplementation on host response to pathogens are controversial. This study investigated the mechanisms by which all-trans retinoic acid (atRA) modulates the host immune response in an experimental model of Vitamin A supplementation before and after challenge with LPS in rats. We show here that a supplementation with five daily injections of 10mg/kg atRA increased the number of T lymphocytes in the peripheral blood.
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