A Novel Model of -Induced Lymphoplasmacytic Rhinosinusitis in Rats.

Chronic rhinosinusitis (CRS) is characterized by sinonasal mucosal inflammation. is associated with severe CRS phenotypes. Different animal models have been proposed to study the association of CRS and .

An In Vitro Study Evaluating the Safety of Mesalazine on Human Nasoepithelial Cells.

Chronic rhinosinusitis (CRS) is a disease characterised by the inflammation of the nasal and paranasal cavities. It is a widespread condition with considerable morbidity for patients. Current treatment for chronic rhinosinusitis consists of appropriate medical therapy followed by surgery in medically resistant patients.

Deferiprone-Gallium-Protoporphyrin Chitogel Decreases Biofilm Infection without Impairing Wound Healing.

is one of the most common pathogens encountered in clinical wound infections. Clinical studies have shown that infection results in a larger wound area, inhibiting healing, and a high prevalence of antimicrobial resistance. Hydroxypyridinone-derived iron chelator Deferiprone (Def) and heme analogue Gallium-Protoporphyrin (GaPP) in a chitosan-dextran hydrogel (Chitogel) have previously been demonstrated to be effective against PAO1 and clinical isolates of in vitro.

Staphylococcal protein A modulates inflammation by inducing interferon signaling in human nasal epithelial cells.

Objective And Design: Staphylococcus aureus (S. aureus) is one of the leading causes of human respiratory tract infections. The function of Staphylococcal protein A (SpA), expressed on the S.

Repetitive simulation training with novel 3D-printed sinus models for functional endoscopic sinus surgeries.

Background: The purpose of this study was to find a utility of a newly developed 3D-printed sinus model and to evaluate the educational benefit of simulation training with the models for functional endoscopic sinus surgery (FESS).

Material And Methods: Forty-seven otolaryngologists were categorized as experts (board-certified physicians with ≥200 experiences of FESS,  = 9), intermediates (board-certified physicians with <200 experiences of FESS,  = 19), and novices (registrars,  = 19). They performed FESS simulation training on 3D-printed models manufactured from DICOM images of computed tomography (CT) scan of real patients.

APTC-C-SA01: A Novel Bacteriophage Cocktail Targeting and MRSA Biofilms.

The high infection and mortality rate of methicillin-resistant Staphylococcus aureus (MRSA) necessitates the urgent development of new treatment strategies. Bacteriophages (phages) have several advantages compared to antibiotics for the treatment of multi-drug-resistant bacterial infections, and thus provide a promising alternative to antibiotics. Here, S.

Deferiprone has anti-inflammatory properties and reduces fibroblast migration in vitro.

Normal wound healing is a highly regulated and coordinated process. However, tissue injury often results in inflammation with excessive scar tissue formation after 40-70% of operations. Here, we evaluated the effect of the iron chelator deferiprone on inflammation and the migration of primary nasal fibroblasts and primary human nasal epithelial cells (HNECs) in vitro.

Management of carotid artery injury in endonasal surgery.

Introduction Carotid artery injury (CAI) is the most feared and potentially catastrophic intraoperative complication an endoscopic skull base surgeon may face. With the advancement of transnasal endoscopic surgery and the willingness to tackle more diverse pathology, evidence-based management of this life-threatening complication is paramount for patient safety and surgeon confidence. Objectives We review the current English literature surrounding the management of CAI during endoscopic transnasal surgery.

Endonasal dacryocystorhinostomy with mucosal flaps.

Purpose: To describe a new endonasal dacryocystorhinostomy (DCR) technique and assess its efficacy.

Design: Prospective nonrandomized interventional case series.

Methods: A prospective series of 44 consecutive endonasal DCRs performed from January 1999 to December 2000 was entered into the study.