Publications by authors named "P-F Chavez"
Article Synopsis
- Mantle cell lymphoma (MCL) varies in prognosis, with blastoid and pleomorphic variants generally having poorer outcomes.
- A study involving 1029 MCL patients over 15 years focused on the characteristics and survival rates of those with these variants, finding a median progression-free survival (PFS) of 38 months and overall survival (OS) of 68 months.
- Key factors influencing PFS included receiving autologous hematopoietic transplantation (auto-HCT) and MCL International Prognostic Index (MIPI) scores; however, auto-HCT did not improve OS, indicating its benefits are more related to managing the disease's progression rather than overall survival.
The human immunological mechanisms defining the clinical outcome of SARS-CoV-2 infection remain elusive. This knowledge gap is mostly driven by the lack of appropriate experimental platforms recapitulating human immune responses in a controlled human lung environment. Here, we report a mouse model (i.
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- The study investigated the effects of neurofeedback training (NFT) on brain activity, specifically focusing on alpha EEG activity, using a double-blind, sham-controlled design with 48 healthy participants divided into NFT and control groups.* -
- Results showed a significant increase in alpha activity for the NFT group, while the control group exhibited no change, and no similar effects were found in other brain wave bands like theta and low beta.* -
- Psychological outcomes indicated both groups experienced increased control, decreased anxiety, and enhanced relaxation, suggesting these effects may be attributed to learning context and placebo rather than direct effects of NFT.*
Data are accumulating that insulin acting in the central nervous system is a physiological regulator of food intake and body weight, presumably via its effect in the hypothalamus. The present study investigated whether infusion of a small dose of insulin into two major hypothalamic insulin-binding areas also has an effect on diet selection and behavior. At the beginning of the dark period, rats received local bilateral infusions of 4 microU of insulin or vehicle during 34 min into the arcuate (ARC) or paraventricular (PVN) nucleus of the hypothalamus.
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