CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia‑induced invasion and therapeutic resistance.

Glioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (EGFRvIII).

Veterinarians show resilience during COVID-19: challenges faced and successful coping strategies.

Objective: To identify challenges veterinarians faced during the COVID-19 pandemic, explore how they coped, identify coping strategies associated with greater resilience, and determine incentives and barriers to performing healthy coping behaviors.

Samples: 266 surveys completed by veterinarians in the Potomac region.

Procedures: A cross-sectional survey was distributed electronically through veterinary medical boards and professional associations between June and September 2021.

Career stage differences in mental health symptom burden and help seeking among veterinarians during COVID-19.

Objective: To explore veterinarians' mental health symptom burden during COVID-19 and identify differences in symptom burden, social support, help seeking, and incentives and barriers associated with receiving help across career stages.

Sample: Online survey responses from 266 veterinarians between June 4 and September 8, 2021.

Procedures: Respondents were grouped by career stage (early [< 5 years of experience], middle [5 to 19 years of experience], or late [≥ 20 years of experience]), and results were compared across groups.

Female fertility treatment and adverse birth outcomes: a multistate analysis of pregnancy risk assessment monitoring system data.

Objective: The popularity of fertility treatments has continued to rise, however, the potential health risks of these treatments for both mother and infant are not fully known. Our objective was to determine the association between fertility treatments and adverse birth outcomes of intended pregnancies using the Pregnancy Risk Assessment Monitoring System (PRAMS) data.

Methods: Data from 27,018 intended pregnancies, collected from 2009 to 2018 in the United States, were included in our analysis.