Publications by authors named "P van de Perre"
People who use drugs show a higher incidence and prevalence of tuberculosis than people who do not use drugs in areas where Mycobacterium tuberculosis is endemic. However, this population is largely neglected in national tuberculosis programmes. Strategies for active case finding, screening, and linkage to care designed for the general population are not adapted to the needs of people who use drugs, who are stigmatised and difficult to reach.
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- The PROMISE-EPI trial tested a combination of strategies to reduce HIV transmission during breastfeeding, showing better results than standard care, particularly through early diagnosis of infants and monitoring of maternal viral load.
- In Zambia, the standard care differs with more complex preventative measures, leading to an exploration of facilitators and barriers related to the new intervention to inform future implementation.
- Qualitative interviews and focus groups highlighted the benefits of integrating key intervention components for immediate action, trust in healthcare, and potential setbacks during disruptions like the COVID-19 pandemic.
Heat of reaction in individual metabolic pathways of yeast determined by mechanistic modeling in an insulated bioreactor.
Biotechnol Biofuels Bioprod
November 2024
Background: The yeast Saccharomyces cerevisiae, commonly used in industry, exhibits complex metabolism due to the Crabtree effect, fermenting alcohol even under aerobic conditions when glucose exceeds 0.10-0.15 g/L.
View Article and Find Full Text PDFRaman spectroscopy and machine learning have become popular in in-line monitoring of bioreactors. However, traditional modeling processes typically entail extensive fermentation batches to collect learning datasets, which are significantly time-consuming and laborious. In addition, these models are limited to configurations with the same conditions as the training batches.
View Article and Find Full Text PDFObjectives: The diagnostic gaps for childhood tuberculosis (TB) remain considerable in settings with high TB incidence and resource constraints. We established and evaluated the performance of a scoring system based on a combination of serological tests and T-cell cytokine release assays, chosen for their ability to detect immune responses indicative of TB, in a context of high prevalence of pediatric HIV infection.
Methods: We enrolled 628 consecutive children aged ≤15 years, admitted for TB suspicion.