Publications by authors named "P van Kerrebroeck"
Nocturia, the need to urinate at night, is a common symptom in patients with obstructive sleep apnoea (OSA). Continuous positive airway pressure treatment can reduce nocturia in some patients, but the underlying mechanisms are complex and not fully understood. OSA affects the autonomic nervous system, oxidative stress and endothelial damage.
View Article and Find Full Text PDFThe International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) E7, the guidance for the conduct of clinical trials in people older than age 65 years, dates from 1994. Since then, the inclusion of older people in clinical trials has hardly improved, particularly for the oldest old age group (individuals older than age 75 years), which is the fastest growing demographic bracket in the EU. Even though most medications are taken by this group, relevant endpoints and safety outcomes for this cohort are rarely included and reported, both in clinical trials and regulatory approval documents.
View Article and Find Full Text PDFBackground: Urology as a separate surgical specialty is a nineteenth century European development. The background of the origins of this new specialty and the elements that were responsible for it have not been studied in detail, although this information is relevant in view of contemporary challenges.
Methods: The existing literature on the history of Urology and original contemporary documents have been researched and analysed.
Context: Midurethral slings (MUSs) are the most used therapy for the treatment of stress urinary incontinence (SUI). While warning signals about potential complications have been raised worldwide, there is a lack of safety data especially in the long term.
Objective: Our objective was to evaluate synthetic MUS safety outcomes at long term in adult women.