Long-term risk of second malignancy in survivors of Hodgkin's disease treated during adolescence or young adulthood.

Purpose: To quantify the long-term risk of second primary cancers (SCs) in patients diagnosed with Hodgkin's disease (HD) during adolescence or young adulthood.

Patients And Methods: The risk of SCs was assessed in 1,253 patients diagnosed with HD before the age of 40 years and treated in two Dutch cancer centers between 1966 and 1986. The median follow-up duration was 14.

Follicular dendritic cell sarcoma and interdigitating reticulum cell sarcoma: a review.

Neoplasms of reticular dendritic origin are extremely rare and include the follicular dendritic cell sarcoma (FDCS) and the interdigitating reticulum (or dendritic) cell sarcoma (IDCS). In this article, we review the literature pertaining to the two diseases and describe clinical observations and salient pathologic features, including information provided by authors of FDCS and IDDCS reports. We performed a computerized database search for published articles regarding FDCS and IDDCS.

Low p53 and high bcl-2 expression in Reed-Sternberg cells predicts poor clinical outcome for Hodgkin's disease: involvement of apoptosis resistance?

A high number of activated cytotoxic T lymphocytes (CTL) in Hodgkin's disease (HD) biopsy specimens is related to an unfavorable clinical outcome, suggesting that resistance of the Hodgkin and Reed-Sternberg (H-RS) cells to CTL-mediated killing is an important pathogenic factor in HD. bcl-2 and defective p53 are known to inhibit apoptosis induced either by CTLs or by therapy. The purpose of this study was to use immunohistochemical techniques to analyze whether differences in expression of these proteins in H-RS cells in primary biopsy specimens from 78 patients with HD were related to clinical outcome and to assess the number of CTLs in those cells.

Detection of malignant cells in cerebrospinal fluid using fluorescence in situ hybridization.

Cytologic examination of cerebrospinal fluid (CSF) is the diagnostic gold standard for leptomeningeal metastasis (LMM). However, this technique is only moderately sensitive when routine staining procedures are applied. The use of fluorescence in situ hybridization (FISH) to identify malignant cells may have an additional value in diagnosing LMM, since numerical chromosomal aberrations (NCA) can be detected at the single cell level.

Histological grading in gastric lymphoma: pretreatment criteria and clinical relevance.

Background & Aims: Stomach-conserving therapy in primary gastric non-Hodgkin's lymphoma (mucosa-associated lymphoid tissue [MALT]-NHL) is increasingly gaining importance as an alternative to surgery. As a consequence, surgical pathologists have to define histological criteria in pretreatment endoscopic biopsy specimen samples not only to make the diagnosis but also to recognize minor tumor components that may infer a significantly adverse impact on prognosis. The aim of this study was to define histological criteria for clinically significant tumor progression in pretreatment endoscopic biopsy specimens.