Publications by authors named "P van Dam"
Herein we present photoinduced cobaloxime-catalyzed selective remote desaturation of aliphatic alcohols. This transformation, which proceeds efficiently at room temperature, facilitates the synthesis of valuable cyclic and acyclic allylic and homoallylic alcohols from readily available saturated aliphatic alcohols. Remarkably, this method obviates the need for external oxidants, noble metal catalysts, and phosphine ligands.
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- Metastatic behavior in liver-metastatic colorectal cancer (CRC) varies significantly based on histopathological growth patterns (HGPs), influencing treatment outcomes, with desmoplastic HGP being linked to favorable and replacement HGP to unfavorable outcomes.
- Understanding cellular and molecular factors of these growth patterns is crucial for improving cancer biology knowledge and designing effective clinical trials.
- Analysis of tumor tissue reveals that HGPs are influenced by epigenetic factors rather than specific gene mutations, with distinct gene expression differences reflecting cancer biology themes, such as inflammation for desmoplastic and cell proliferation for replacement patterns.
CineECG Repolarization Gradients Predict Acute Hemodynamic Response in CRT Patients.
J Cardiovasc Electrophysiol
December 2024
Article Synopsis
- - The study investigates the effectiveness of a new ECG technique called CineECG, which visualizes heart electrical activity, in improving cardiac resynchronization therapy (CRT) for patients who don't respond well to standard treatments.
- - Researchers analyzed CineECG data from 15 patients with heart conditions under different pacing settings and found that specific movement directions in the heart's electrical signals correlate with better immediate heart performance (measured as dP/dt max).
- - The results indicate that the direction of the ST-T segment during repolarization can predict a significant improvement in heart function during CRT, suggesting that CineECG could help optimize treatment plans for patients.
Background: The phase II PRIMMO trial investigated a pembrolizumab-based regimen in patients with recurrent and/or metastatic cervical (CC) or endometrial (EC) carcinoma who had at least one prior line of systemic therapy. Here, exploratory studies of the gut microbiome (GM) are presented.
Methods: The microbial composition of 77 longitudinal fecal samples obtained from 35 patients (CC, n = 15; EC, n = 20) was characterized using 16S rRNA gene sequencing.