Publications by authors named "P du Cros"
Setting: Papua New Guinea is a high-burden multidrug-resistant TB (MDR/RR-TB) country that reports low rates of bacteriological confirmation. Sputum drug susceptibility testing for second-line drugs is important. Access to culture is limited.
View Article and Find Full Text PDFCommunity-Wide Active Case Finding for Tuberculosis: Time to Use the Evidence We Have.
Trop Med Infect Dis
September 2024
Tuberculosis, caused by the () bacteria, is one of the world's deadliest infectious diseases. Despite being the world's oldest pandemic, tuberculosis is very much a challenge of the modern era. In high-incidence settings, all people are at risk, irrespective of whether they have common vulnerabilities to the disease warranting the current WHO recommendations for community-wide tuberculosis active case finding in these settings.
View Article and Find Full Text PDFImpact of respiratory pathogens detection by a rapid multiplex polymerase chain reaction assay on the management of community-acquired pneumonia for children at the paediatric emergency department. A randomized controlled trial, the Optimization of Pneumonia Acute Care (OPTIPAC) study.
Aymeric Cantais Sylvie Pillet Josselin Rigaill François Angoulvant Christele Gras-Le-Guen Pierrick Cros
Clin Microbiol Infect
January 2025
Article Synopsis
- The study examines whether rapid multiplex PCR testing in the emergency department can enhance the treatment of community-acquired pneumonia (CAP) in children compared to standard care.
- Conducted in 11 French centers between 2016-2018, the study included 499 children, with some receiving the PCR test and others only standard care, and tracked the effectiveness of initial antibiotic treatments over 15 days.
- Results showed a significant improvement in antibiotic treatment appropriateness in the PCR group, particularly reducing unnecessary antibiotics for viral pneumonia, indicating better antimicrobial stewardship without adverse effects.