Publications by authors named "P de Viragh"
Article Synopsis
- Female androgenetic alopecia (FAGA) is the most common type of hair loss in women, showing a patterned progression in hair thinning.
- Various oral treatments, including spironolactone and reduced androgen activity medications, can help manage FAGA, but concerns exist about their use in women with past gynecological cancers.
- A review indicates that spironolactone is generally safe for treating FAGA, even for high-risk patients, but more research is needed to determine the safety of other treatments for those with gynecologic cancer histories.
Importance: Poor therapeutic results have been reported in patients with alopecia areata totalis (AT) or universalis (AU), the most severe and disabling types of alopecia areata (AA). Methotrexate, an inexpensive treatment, might be effective in AU and AT.
Objective: To evaluate the efficacy and tolerance of methotrexate alone or combined with low-dose prednisone in patients with chronic and recalcitrant AT and AU.
The use of highly inducible HSP promoters for exerting spatial and/or temporal control over the expression of therapeutic transgenes has long been discussed. Localized and time-limited induction of the heat shock response may potentially also be of medical interest. However, such applications would require targeted delivery of heat doses capable of activating HSP promoters in tissues or organs of interest.
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