Publications by authors named "P de Sequera"
Introduction: Chronic kidney disease (CKD) of non-inherited etiology is one of the main causes of renal replacement therapy in our setting. Previous studies in other territories suggest that hereditary diseases could be one of the potential causes of this pathology, especially in younger patients. The GENSEN study will evaluate the presence of pathogenic genetic variants in subjects who have developed CKD category G5 before the age of 46 years, of non-inherited etiology.
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- Chronic kidney disease of unknown etiology (CKDUE) is a leading global cause of kidney failure, and the GENSEN Study aimed to explore its genetic causes through extensive genetic testing on a large patient population.
- The study involved 818 patients under 45 with advanced CKDUE, discovering pathogenic gene variants in about 25% of them, with type IV collagen genes being the most commonly affected.
- The research revealed significant previously undiagnosed genetic kidney diseases, suggesting that genomic testing can be a valuable approach in understanding and treating CKDUE.
Article Synopsis
- Most signs and symptoms of heart failure stem from fluid overload, which complicates both diagnosis and treatment as it relates to disease progression.
- Effective management requires a multiparametric approach that incorporates clinical data, imaging tests, and biomarkers.
- The article, produced by Spanish medical societies, suggests practical strategies for treating hydrosaline overload in heart failure for patients in both inpatient and outpatient settings.
Background: The coexistence of heart and kidney diseases, also called cardiorenal syndrome, is very common, leads to increased morbidity and mortality, and poses diagnostic and therapeutic difficulties. There is a risk-treatment paradox, such that patients with the highest risk are treated with lesser disease-modifying medical therapies.
Summary: In this document, different scientific societies propose a practical approach to address and optimize cardiorenal therapies and related comorbidities systematically in chronic cardiorenal disease beyond congestion.