Publications by authors named "P Zakrzewski"
Introduction: Breast cancer is highly metastatic. One protein that may participate in breast cancer cell migration is the actin motor protein myosin 6 (MYO6), which is likely regulated by the GIPC1 protein. Additionally, septins (SEPTs) appear to participate in breast cancer motility.
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- Neutrophil activation needs careful control to prevent diseases, as uncontrolled neutrophil extracellular traps (NETs) can cause more harm than good.
- A receptor called MICL helps keep this process in check by recognizing DNA in NETs, and when it doesn't work properly, it can lead to too many NETs being formed.
- In diseases like rheumatoid arthritis and lupus, there are autoantibodies that block MICL, which worsens the disease, but during certain infections, like with a fungus, having more NETs can actually help fight off the infection.
Background: Coronary access (CA) is a major concern in redo-transcatheter aortic valve implantation (TAVI) for failing supra-annular self-expanding transcatheter aortic valves (TAVs).
Aims: This ex vivo study evaluated the benefit of leaflet splitting (LS) on subsequent CA after redo-TAVI in anatomies deemed at high risk of unfeasible CA.
Methods: Ex vivo, patient-specific models were printed three-dimensionally.
Background: Neutrophils are granulocytes with essential antimicrobial effector functions and short lifespans. During infection or sterile inflammation, emergency granulopoiesis leads to release of immature neutrophils from the bone marrow, serving to boost circulating neutrophil counts. Steady state and emergency granulopoiesis are incompletely understood, partly due to a lack of genetically amenable models of neutrophil development.
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