Group IV Bimetallic MOFs Engineering Enhanced Metabolic Profiles Co-Predict Liposarcoma Recognition and Classification.

The rarity and heterogeneity of liposarcomas (LPS) pose significant challenges in their diagnosis and management. In this work, a series of metal-organic frameworks (MOFs) engineering is designed and implemented. Through comprehensive characterization and performance evaluations, such as stability, thermal-driven desorption efficiency, as well as energy- and charge-transfer capacity, the engineering of group IV bimetallic MOFs emerges as particularly noteworthy.

Immunomodulation with M2 macrophage-derived extracellular vesicles for enhanced titanium implant osseointegration under diabetic conditions.

M2 macrophage-derived extracellular vesicles (M2-EVs) demonstrate the capacity to reduce pro-inflammatory M1 macrophage formation, thereby restoring the M1-M2 macrophage balance and promoting immunoregulation. However, the efficacy of M2-EVs in regulating macrophage polarization and subsequently enhancing osseointegration around titanium (Ti) implants in patients with diabetes mellitus (DM) remains to be elucidated. In this study, Ti implants were coated with polydopamine to facilitate M2-EVs adherence.

Pressure-Induced Assembly of Organic Phase-Change Materials Hybridized with Expanded Graphite and Carbon Nanotubes for Direct Solar Thermal Harvesting and Thermoelectric Conversion.

Direct harvesting of abundant solar thermal energy within organic phase-change materials (PCMs) has emerged as a promising way to overcome the intermittency of renewable solar energy and pursue high-efficiency heating-related applications. Organic PCMs, however, generally suffer from several common shortcomings including melting-induced leakage, poor solar absorption, and low thermal conductivity. Compounding organic PCMs with single-component carbon materials faces the difficulty in achieving optimized comprehensive performance enhancement.

Elucidating the role of gut microbiota metabolites in diabetes by employing network pharmacology.

Background: Extensive research has underscored the criticality of preserving diversity and equilibrium within the gut microbiota for optimal human health. However, the precise mechanisms by which the metabolites and targets of the gut microbiota exert their effects remain largely unexplored. This study utilizes a network pharmacology methodology to elucidate the intricate interplay between the microbiota, metabolites, and targets in the context of DM, thereby facilitating a more comprehensive comprehension of this multifaceted disease.

A Neuronal Signal Sorting and Amplifying Nanosensor for EEG-Concordant Imaging-Guided Precision Epilepsy Ablation.

Surgery remains an essential treatment for managing drug-resistant focal epilepsy, but its accessibility and efficacy are limited in patients without distinct structural abnormalities on magnetic resonance imaging (MRI). Potassium ion (K), a critical marker for seizure-associated neuronal signaling, shows significant promise for designing sensors targeting hidden epileptic foci. However, existing sensors cannot cross the blood-brain barrier and lack the ability to specifically enrich and amplify K signals in the brain with high temporal and spatial resolution.