Publications by authors named "P Z Feczko"
Article Synopsis
- The study aimed to evaluate a home-based prehabilitation program for total knee arthroplasty patients to see if it could help improve recovery times and outcomes compared to those not participating in the program.
- Conducted as a retrospective cohort study, patients scheduled for knee surgery were compared to historical cases, focusing on those with mobility challenges.
- Results showed the program was feasible, with high recruitment and adherence rates, and participants demonstrated significant preoperative improvements in physical fitness and quicker recovery timelines post-surgery.
Objective: To identify patients at high risk of delayed in-hospital functional recovery after knee replacement surgery by developing and validating a prediction model, including a combination of preoperative physical fitness parameters and patient characteristics.
Design: Retrospective cohort study using binary logistic regression.
Setting: University hospital, orthopedic department.
Article Synopsis
- The research aimed to compare the chondrocyte signaling profiles between non-osteoarthritic and end-stage osteoarthritic knee synovial fluid to understand their effects on cartilage cells.
- Protein profiling techniques were employed to analyze the different signaling patterns and their consequences on chondrocyte behavior.
- Findings revealed that osteoarthritic synovial fluid has more inflammatory cytokines and growth factors, leading to altered signaling that promotes abnormal chondrocyte behavior and contributes to cartilage degeneration.
Osteoarthritis presents as a change in the chondrocyte phenotype and an imbalance between anabolic and catabolic processes. Age affects its onset and progression. Small nucleolar RNAs (SnoRNAs) direct chemical modification of RNA substrates to fine-tune spliceosomal and rRNA function, accommodating changing requirements for splicing and protein synthesis during health and disease.
View Article and Find Full Text PDFEnhanced recovery in usual health care improves functional recovery after total knee arthroplasty.
Int J Orthop Trauma Nurs
August 2019
Background: The success of total knee arthroplasty (TKA) is determined by an effective surgical procedure as well as a well-organized clinical care pathway. Research has shown that day-of-surgery mobilization decreases length of stay (LOS) and complication rates. We developed, implemented, and evaluated a new clinical care pathway for patients undergoing TKA, that included early mobilization, using 'Lean Six Sigma (LSS)', with the aim of accelerating functional recovery and reducing LOS.
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