Phenotype variability in diet-induced obesity and response to (-)-epigallocatechin gallate supplementation in a Diversity Outbred mouse cohort: A model for exploring gene x diet interactions for dietary bioactives.

The flavan-3-ol (-)-epigallocatechin gallate (EGCG) blunts obesity in inbred mice, but human clinical trials have yielded mixed results. Genetic homogeneity in preclinical models may explain translational disconnect between rodents and humans. The Diversity Outbred (DO) mouse model provides genotype and phenotype variability for characterization of gene x environment (i.

Gas exchange and time to reach maximum rate of photosynthetic rate and their relationship with whole-plant traits in sugarcane in water abundant Louisiana, USA.

Variety development of sugarcane ( spp. hybrids) is necessary to continue improving sugar yields and selecting photosynthetic traits can improve sugar production through increased carbon inputs. In this study, gas exchange and whole-plant measurements were made on 55 sugarcane genotypes in Louisiana.

Neonatal epididymo-orchitis caused by : A case of successful non-surgical management.

Neonatal epididymo-orchitis (EO) is a rare condition, particularly when caused by S, a pathogen typically associated with gastroenteritis. We present the case of a 15-day-old male who developed right-sided scrotal swelling and erythema. Scrotal ultrasound confirmed EO without signs of torsion or abscess.

Acquired hemophilia A: a narrative review and management approach in the emicizumab era.

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by inhibitory autoantibodies to factor (F)VIII. The goals of treatment are 2-fold, namely immunosuppressive therapy to eradicate the inhibitor and hemostatic management to control bleeding. Emicizumab, a bispecific antibody that acts as a FVIIIa-mimetic, has seen growing use in AHA following its approval for congenital hemophilia A.