Publications by authors named "P Yuridia L Alvarado Bernal"
Article Synopsis
- A Controlled Human Infection Model (CHIM) with wild-type Salmonella Typhi was set up to study immunity development, revealing that about 55% of volunteers met typhoid diagnosis criteria after infection.
- Intestinal macrophages, which play a crucial role in gut defense, are derived from circulating monocytes rather than tissue-resident progenitors, making them unique compared to macrophages in other organs.
- Changes in circulating monocytes were tracked post-infection, showing that typhoid diagnosis participants had increased activation markers, indicating a heightened immune response, and upregulated molecules to interact with both bacterial antigens and adaptive immune cells.
Executive Summary: Microbes are all pervasive in their distribution and influence on the functioning and well-being of humans, life in general and the planet. Microbially-based technologies contribute hugely to the supply of important goods and services we depend upon, such as the provision of food, medicines and clean water. They also offer mechanisms and strategies to mitigate and solve a wide range of problems and crises facing humanity at all levels, including those encapsulated in the sustainable development goals (SDGs) formulated by the United Nations.
View Article and Find Full Text PDFGram-negative bacteria use the T6SS to eject effectors into prey cells, aided by delivery domains. Recently uncovered by Carobbi et al., a new delivery domain, PIX, allowed the identification of hundreds of new effectors.
View Article and Find Full Text PDFBackground: Dengue human infection models (DHIMs) are important tools to down-select dengue vaccine candidates and establish tetravalent efficacy before advanced clinical field trials. We aimed to provide data for the safety and immunogenicity of DHIM and evaluate dengue vaccine efficacy.
Methods: We performed an open-label, phase 1 trial at the University of Maryland (Baltimore, MD, USA).