Publications by authors named "P Y Tung"
Aims: This study examined the association of gravida C-peptide with progeny islet function and insulin sensitivity in the Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS).
Methods: Pregnancy 3rd trimester oral glucose tolerance test (OGTT), cord blood, and offspring OGTT glucose, C-peptide and insulin at age 10-14 years were analyzed for 4,121 mother-child dyads. Gravida fasting and 1-hour C-peptide concentration correlations with cord blood and childhood C-peptide, insulin, insulinogenic index and insulin sensitivity, and insulin resistance [HOMA-IR]), were assessed by multiple linear regression.
Article Synopsis
- The study investigates the presence of tDRs (tissue-specific RNAs) in human milk extracellular vesicles (EVs) and how they relate to various maternal factors like body mass index, age, and diet among a Latina population.
- The research involved sequencing small RNAs from 109 milk samples collected one month postpartum and analyzing their associations with maternal characteristics using statistical models.
- Results showed 338 tDRs, with 113 common across all samples, linked to factors such as the time of milk collection, breastfeeding patterns, and the mother's dietary inflammatory index, highlighting the potential influence of these variables on tDR expression in breast milk.
Background: Pulmonary vein isolation (PVI) is superior to antiarrhythmics for the management of atrial fibrillation, but repeat ablation is often required for durable rhythm control. Factors influencing first-pass isolation (FPI) and whether FPI predicts durable isolation are not well known.
Objective: The study sought to determine factors associated with FPI and rates of chronic reconnection among those with and without FPI at index PVI in patients undergoing repeat ablation.
Article Synopsis
- Low mtDNA copy number (mtDNAcn) in early life has been linked to cognitive decline, but its impact on healthy cognitive development in children is still unclear.
- The study measured mtDNAcn in umbilical cord blood and child blood at ages 5-7 and analyzed cognitive performance later using standardized tests, finding that both low and high mtDNAcn were associated with poorer cognitive outcomes.
- Results suggest mtDNAcn may be an important biomarker for assessing neurocognitive performance in children, highlighting the need for further research on mitochondrial markers in healthy populations.
Dammarane-Type Saponins from the Leaves of Vietnamese Ginseng (Panax vietnamensis Ha & Grushv.) and Their Acetylcholinesterase Inhibition In Vitro and In Silico.
Chem Biodivers
October 2024
Article Synopsis
- Vietnamese ginseng (Panax vietnamensis) is well-known for its medicinal properties, particularly due to bioactive compounds called ginsenosides found mainly in its rhizome.
- A recent study identified seven ginsenosides in the leaves of Vietnamese ginseng, notably ginsenoside Rd and pseudoginsenoside RS1, which showed significant inhibition of the enzyme acetylcholinesterase, important for memory function.
- The research suggests that the leaves could be an alternative source for enhancing memory, providing a basis for further exploration into their potential anti-dementia benefits.