Publications by authors named "P Y A Reinke"
Article Synopsis
- The Centre of Excellence for the Technologies of Gene and Cell Therapy (CTGCT) has been established at the National Institute of Chemistry in Ljubljana, marking Slovenia’s first center dedicated to precision medicine and cutting-edge therapies.
- The CTGCT aims to advance cancer immunotherapy and personalized treatments for genetic diseases by developing innovative biomedical tools and collaborating with international institutions for effective therapy development.
- Its focus on translating research into practice, alongside partnerships with clinicians and patient organizations, positions the CTGCT as a key player in improving access to gene and cell therapies across Slovenia and the broader Eastern European region.
Cables formed by head-to-tail polymerization of tropomyosin, localized along the length of sarcomeric and cytoskeletal actin filaments, play a key role in regulating a wide range of motile and contractile processes. The stability of tropomyosin cables, their interaction with actin filaments and the functional properties of the resulting co-filaments are thought to be affected by N-terminal acetylation of tropomyosin. Here, we present high-resolution structures of cables formed by acetylated and unacetylated Schizosaccharomyces pombe tropomyosin ortholog Tpm.
View Article and Find Full Text PDFRegulatory T cells (T cells) hold promise for sustainable therapy of immune disorders. Recent advancements in chimeric antigen receptor development and genome editing aim to enhance the specificity and function of T cells. However, impurities and functional instability pose challenges for the development of safe gene-edited T cell products.
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- Human herpesvirus 6 (HHV-6) has two types, HHV-6A and HHV-6B, with HHV-6A being more prevalent in kidney transplant patients.
- A study involving 93 patients showed that HHV-6A was found in over half of the participants, while HHV-6B was much less common, and the viral loads for HHV-6A were significantly higher than those of other viruses tested.
- Despite high levels of HHV-6A, no negative impact on kidney function or overall health was observed in patients one year post-transplant.