The Regulatory Role of Pancreatic Enzymes in the Maintenance of Small Intestinal Structure and Enterocyte Turnover with Special Reference to Alpha Amylase.

The aim of this study was to elucidate the impact of porcine pancreatic enzymes (Creon pancrelipase) in comparison to microbial-derived alpha amylase (MD amylase) on the small intestine wall structure, mucosal glycogen accumulation, and enterocyte turnover. The impact of enzyme supplementation on the small intestine was explored in 18 pigs with surgically induced exocrine pancreatic insufficiency (EPI). Four healthy pigs served as the control group.

Investigating the Influence of a Tooth Absence on Facial Bone Growth Using a Porcine Model.

With the current state of knowledge regarding disorders of facial bone development, including anodontia, the development of a suitable animal model for preclinical studies is essential. The agenesis of dental buds occurs in about 25% of the human population. Prospects for treatment include the use of growth factors, stem cells, and bioengineering.

Modified throughput ninhydrin method for the qualitative assessment of dietary protein absorption in pig plasma.

Protein maldigestion and malabsorption lead to malnutrition and are a feature of exocrine pancreatic insufficiency (EPI). Although it is the current standard, measurement of nitrogen in stool to assess protease activity is indirect. Up to 80% of hydrolysed proteins appear in blood in the form of peptides, so we developed a method to measure peptide-derived amino acids in plasma as a relevant measure of proteolysis, verified its accuracy, precision, and linearity, and validated it in a porcine model.

A new technique of alveolar bone augmentation: "Pack into Bone". A retrospective case-series study.

Purpose: To provide an overview of an innovative surgical approach to guided bone regeneration, the Pack Into Bone (PIB) technique.

Methods: Twenty subjects, eight men and 12 women, aged 34 to 68 (mean 51.5) were selected.

Bone into Bone technique: An alternative to horizontal bone regeneration techniques. Retrospective case-control study.

Purpose: To evaluate the efficacy of lateral ridge augmentation (LRA) of porcine cortical barriers when placed in a surgical bone gap, buccal to the defect, using the Bone into Bone (BiB) technique compared to a guided bone regeneration (GBR) technique.

Methods: The study was a retrospective case-control evaluation. A group of 23 subjects (test) underwent horizontal augmentation procedures using the BiB technique.