Publications by authors named "P Woodland"
Background & Aims: Dilated intercellular space in esophageal epithelium, a sign of impaired barrier function, is a characteristic finding of gastroesophageal reflux disease that is also found in obese patients without gastroesophageal reflux disease. We explored molecular mechanisms whereby adipose tissue products might impair esophageal barrier integrity.
Methods: Cultures of visceral fat obtained during foregut surgery from obese and nonobese patients were established.
Article Synopsis
- Survival rates for esophageal squamous cell carcinoma (ESCC) are low due to late diagnosis, prompting research into early molecular changes that could aid in earlier detection.
- The study examined esophageal biopsies from individuals with Tylosis with esophageal cancer (TOC), a syndrome linked to higher ESCC risk, identifying significant transcriptional changes that were also seen in ESCC.
- Results indicated that these early changes may be crucial in understanding how sporadic ESCC develops and highlighted specific upregulated genes like Keratin 17 that could serve as potential biomarkers.
Article Synopsis
- The study investigates differences in immune cell signatures and sensory markers in various reflux disease phenotypes compared to healthy subjects.
- Thirty-seven patients were categorized into four groups (ERD, NERD, FH, and BO) and their tissue samples analyzed through mRNA sequencing and immunofluorescent staining.
- Results showed increased mast cell abundance and decreased dendritic cell infiltration in GERD patients, along with higher nerve growth factor expression in mast cells, indicating potential mechanisms for esophageal sensitivity and immune response development.
Background: Mechanisms underlying perception of dysphagia and chest pain have not been completely elucidated, although oesophageal mucosal afferent nerves might play an important role.
Aims: To evaluate the relationship between oesophageal mucosal afferent nerves and the severity of dysphagia and chest pain in oesophageal motility disorders.
Methods: We prospectively recruited patients with oesophageal motility disorders having dysphagia and/or chest pain from whom oesophageal biopsies were obtained.
This study examined the effects of veteran-specific cooperative police interventions, including a Veterans Response Team (VRT) and broad collaboration between local police departments and a Veterans Affairs (VA) medical center police department (local-VA police [LVP]), on veterans' health care utilization. Data were analyzed on 241 veterans (51 received VRT and 190 received LVP intervention) in Wilmington, Delaware. Nearly all veterans in the sample were enrolled in VA health care at the time of police intervention.
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