Publications by authors named "P Wiesli"

We report a case of an 89-year-old patient, who presented with melena and physical degradation at the emergency department. As cause for his symptoms, we found an upper GI-bleeding from a metastasis of a follicular thyroid carcinoma, for which the patient was surgically treated in the year 1996.

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Diabetes is a well-recognised risk factor for the development of heart failure, with a prevalence higher than 30% in patients with diabetes aged over 60 years. Heart failure often emerges as the primary cardiovascular manifestation in patients with type 2 diabetes and appears to be even more prevalent in type 1 diabetes. In Switzerland, there are approximately 500,000 individuals with diabetes, and the number of affected people has been steadily rising in recent years.

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GLP-1 Receptor Agonists: For Which Patients with Type-2 Diabetes? In the last few years, the cardiovascular outcome trials for SGLT-2 inhibitors and GLP-1 receptor agonists showed them to significantly lower the risk of cardiorenal endpoints in patients with type-2 diabetes when compared to other antidiabetics. This effect was independent of concurrent medication. This additional benefit is well established in the case of SGLT-2 inhibitors, leading to increased prescription.

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As a first step, the authors emphasise lifestyle changes (increased physical activity, stopping smoking), blood pressure control, and lowering cholesterol). The initial medical treatment should always be a combination treatment with metformin and a sodium-glucose transporter 2 (SGLT-2) inhibitor or a glucagon-like 1 peptide (GLP-1) receptor agonist. Metformin is given first and up-titrated, followed by SGLT-2 inhibitors or GLP-1 receptor agonists.

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Aims: Glucose and insulin metabolism are altered in hemodialysis patients, and diabetes management is difficult in these patients. We aimed to validate flash glucose monitoring (FGM) in hemodialysis patients with and without diabetes mellitus as an attractive option for glucose monitoring not requiring regular self-punctures.

Methods: We measured interstitial glucose using a FreeStyle Libre device in eight hemodialysis patients with and seven without diabetes mellitus over 14 days and compared the results to simultaneously performed self-monitoring of capillary blood glucose (SMBG).

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