Publications by authors named "P Wenzel"
Pancreatic Cancer: Current Concepts, Trends, and Future Directions.
Turk J Gastroenterol
November 2024
Article Synopsis
- - Pancreatic ductal adenocarcinoma (PC) is a highly aggressive cancer with a low survival rate, projected to become the second leading cause of cancer deaths in the coming decades due to its resistance to treatment.
- - Recent advancements in clinical trials have improved patient survival, with new therapeutic strategies emerging, including adjuvant, neoadjuvant, and palliative treatments aimed at extending life expectancy.
- - The role of molecular tumor boards and genetic profiling is highlighted as vital for enhancing treatment options and customizing therapies, especially with the introduction of targeted therapies like KRAS inhibitors, steering future research directions.
Parotid sialolithiasis - Long term follow-up analyzing surgical approaches.
Laryngoscope Investig Otolaryngol
December 2024
Objectives: Present follow-up data comparing transoral and transfacial parotid gland procedures for stone removal to offer insight addressing technical considerations and complications.
Methods: Retrospective study of a consecutive series of surgical treatments for parotid sialolithiasis from 2013 to 2018 at an academic institution by one surgeon provided review of 16 transoral and 10 transfacial procedures supplemented by long-term follow-up through telephone or mail. Clinical and radiographic parameters, additional treatment, and persistence of symptoms were evaluated.
Article Synopsis
- This study analyzes how different platelet collagen receptors (GPVI, α2β1, and GPIb-IX-V) interact with various sources of collagen, impacting platelet activation and thrombus formation.
- Ethical collagens tested include type I collagen from equine tendon, rat tail, and acid-soluble collagen from human umbilical cord.
- The results show varied reliance on receptors for platelet aggregation depending on the collagen type, with GPVI playing a crucial role in reducing thrombus parameters when inhibited, demonstrating that collective receptor interactions influence platelet behavior on different collagen surfaces.
Objective: Identify correlations between lymph node characteristics and extranodal extension (ENE).
Study Design: Retrospective chart review.
Setting: Tertiary care center.