Dopamine and opiate receptors: localization in the striatum and evidence for their axoplasmic transport in the nigrostriatal and striatonigral pathways.

The axoplasmic transport of dopamine and opiate receptors in the striatonigral and nigrostriatal pathways was investigated by placing coronal knife cuts through these pathways and examining autoradiographically the accumulation of receptors at the site of the cut. In otherwise normal animals build-up of both receptors was found both rostral and caudal to the cut after a survival time of 24 h. Build-up of both receptors was reduced caudal to the cut by prior 6-hydroxydopamine lesions of the substantia nigra-ventral tegmental area, and reduced rostral to the cut by prior kainic acid lesions of the striatum.

Empirical assessment of identity in anorexia and bulimia nervosa.

Researchers have neglected the study of the self concept of individuals who develop anorexia and bulimia nervosa. Towards rectifying this situation, Identity Structure Analysis (ISA) is introduced as an appropriate framework allowing the specification and empirical testing of postulates regarding disturbed identity development in anorexic disorders. The data presented distinguish a common constellation of identity characteristics in those suffering from anorexia and bulimia nervosa that differentiate them from normal and psychiatric control groups.

Multiple binding sites for [3H]clonidine and [3H]WB-4101 in rat brain.

Binding of the alpha-adrenergic agonist [3H]clonidine and the alpha-adrenergic antagonist [3H]WB-4101 exhibited multiple binding site characteristics in both rat frontal cortex and cerebellum. Kinetic analysis of the dissociation of both radioligands in rat frontal cortex suggests two high affinity sites for each ligand. Competition of various noradrenergic agonists and antagonists for [3H]WB-4101 binding yielded shallow competition curves, with Hill coefficients ranging from 0.