Publications by authors named "P Weinberger"
Article Synopsis
- Researchers have been focused on combining spin crossover (SCO) with guest incorporation properties, leading to the development of various spin crossover porous coordination polymers (SCO-PCPs), notably the Hofmann-type network, which is useful for (chemo)sensing applications.
- Efforts to create larger cavity structures from the classic SCO-PCP framework {Fe(pz)[M(CN)]} (where M can be Ni, Pd, or Pt) have often resulted in compounds with weaker magnetic properties.
- This study presents new wide-mesh-size SCO Hofmann-type networks with enhanced porosity and larger cavities, while maintaining key SCO behaviors such as hysteresis and guest-dependent spin-switching, successfully characterizing their structural
Article Synopsis
- Anaplastic thyroid carcinoma is one of the deadliest cancers and frequently occurs alongside differentiated thyroid cancers, but its aggressive nature is not well understood.
- Researchers analyzed tumor DNA from 329 regions of thyroid cancer, revealing that anaplastic thyroid carcinomas have more mutations and unique mutational patterns compared to other thyroid cancers.
- The study shows that although anaplastic and differentiated thyroid carcinomas can occur in the same patient, they have different mutated genes and share a common genetic origin that allows them to develop from a similar malignant environment.
The North American Airway Collaborative (NoAAC) previously published a 3-year multi-institutional prospective cohort study showing variation in treatment effectiveness between 3 primary surgical techniques for idiopathic subglottic stenosis (iSGS). In this report, we update these findings to include 5 years of data evaluating treatment effectiveness. Patients in the NoAAC cohort were re-enrolled for 2 additional years and followed using the prespecified published protocol.
View Article and Find Full Text PDFBackground & Aims: Genetic factors such as the transmembrane 6 superfamily 2 (TM6SF2) rs58542926 single nucleotide variant(SNV) modulate the susceptibility for (advanced) chronic liver disease ([A]CLD). However, the impact of this variant in patients who have already progressed to ACLD is unknown.
Methods: The association between TM6SF2-rs58542926 genotype and liver-related events was evaluated in 938 ACLD patients undergoing hepatic venous pressure gradient (HVPG) measurement.
Background & Aims: Alpha-1 antitrypsin (AAT) deficiency causes/predisposes individuals to advanced chronic liver disease (ACLD). However, the role of the Pi∗Z allele in patients who have already progressed to ACLD is unclear. Thus, we aimed to evaluate the impact of the Pi∗Z allele on the risk of liver transplantation/liver-related death in patients with ACLD, while adjusting for the severity of liver disease at inclusion.
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