Publications by authors named "P Watcho"
Mondia whitei is an aromatic plant native to sub-Saharan Africa. This spice is commonly used in the treatment of various diseases, such as hypertension, diabetes, erectile dysfunction, and premature ejaculation. This review was undertaken to provide updated information on the botanical, phytochemical, pharmacological, and toxicological knowledge of this plant of high relevance to African populations.
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- - The study evaluated the effects of Vepris afzelii root extract on male rats with hypogonadism induced by cyproterone acetate, showing significant alterations in sexual behavior and reproductive parameters after treatment.
- - The experiment included 36 adult Wistar rats divided into groups, with some receiving distilled water, testosterone, or varying doses of the extract over a 14-day period.
- - Key findings indicated significant reductions in sexual activity, sperm mobility, and testosterone levels in hypogonadal rats, while treatment with the extract improved several reproductive metrics compared to controls.
Objectives: The ethanol extract of seeds was found to inhibit the development of estrogen-dependent conditions in female Wistar rats, suggesting the ability of its secondary metabolites to interact with estrogen receptors (ERs), either as partial agonists or as antagonists. To test this hypothesis, the abovementioned extract was assessed for its ability to mimic and/or antagonize estradiol effects.
Methods: Two experiments were conducted in ovariectomized (OVX) rats: (1) animals were treated with estradiol valerate (EV; 1 mg/kg) or at doses of 25 and 50 mg/kg; (2) animals were treated with EV alone (0.
COVID-19, which was named in March 2020 as a global pandemic by the WHO, remains a serious public health threat worldwide. Despite the adoption of vaccines as an effective strategy to counter this pandemic, the vaccination rate in Cameroon is far lower than that planned by the Cameroonian government and its partners. The main objective of this study was to determine the factors limiting COVID-19 vaccine acceptance in the Menoua Division in the West Region of Cameroon.
View Article and Find Full Text PDFBackground: Cyclophosphamide (CP) is an anticancer agent, but its chronic administration induces ovarian toxicity.
Objective: We evaluated the effects of aqueous extract (AE) and methanol extract (ME) of ( ) on CP-induced ovarian toxicity in rats.
Materials And Methods: 40 female Wistar rats (10 wk, 170-200 gr) were distributed into 8 groups (n = 5/each) as follows: 1) healthy control; 2) CP+distilled water (10 ml/kg/d); 3) CP+3%-tween 80 (10 mL/kg/d); 4) CP+clomiphene citrate (2 mg/kg/d); 5, 6) CP+AE of (55 and 110 mg/kg/d); and 7, 8) CP+ME of (55 and 110 mg/kg/d).