Publications by authors named "P W Rogers"
Study Question: Can a panel of plasma protein biomarkers be identified to accurately and specifically diagnose endometriosis?
Summary Answer: A novel panel of 10 plasma protein biomarkers was identified and validated, demonstrating strong predictive accuracy for the diagnosis of endometriosis.
What Is Known Already: Endometriosis poses intricate medical challenges for affected individuals and their physicians, yet diagnosis currently takes an average of 7 years and normally requires invasive laparoscopy. Consequently, the need for a simple, accurate non-invasive diagnostic tool is paramount.
Background: Secretoneurin, a member of the granin protein family, is associated with the risk of mortality in patients with acute and chronic heart failure. Secretoneurin may play an important role in cardiomyocyte calcium handling, suggesting that it may influence cardiac arrhythmia risk. We hypothesized that baseline and serial measurements of circulating secretoneurin are associated with the risk of incident ventricular tachyarrhythmias (VA) and death, and that serial measurement would provide prognostic information beyond baseline values.
View Article and Find Full Text PDFReduced exposure to sweet taste has been proposed to reduce sweet food preferences and intakes, but the evidence to support these associations is limited. This randomised controlled trial investigated the effects of a whole-diet sweet taste intervention for 6 days, on subsequent pleasantness, desire for, and sweet food intakes. Participants ( 104) were randomised to increase ( 40), decrease ( 43), or make no change to ( 21) their consumption of sweet-tasting foods and beverages for six consecutive days.
View Article and Find Full Text PDFArticle Synopsis
- Colorectal anastomotic devices have been used for almost 100 years, with stapled methods being most common, despite a significant leak risk of up to 20%.
- A systematic review and meta-analysis explored newer anastomotic devices, analyzing 18 studies from the last decade, which included 955 anastomoses and focused on non-stapled methods.
- The findings indicated a pooled complication rate of 9.7% for human studies, but new compression mechanisms showed a much lower leak rate of 3.3%, suggesting that these novel technologies could improve surgical outcomes.