Publications by authors named "P W Kok"
Platinum-based chemotherapy in combination with anti-PD-L1 antibodies has shown promising results in mesothelioma. However, the immunological mechanisms underlying its efficacy are not well understood and there are no predictive biomarkers to guide treatment decisions. Here, we combine time course RNA sequencing (RNA-seq) of peripheral blood mononuclear cells with pre-treatment tumor transcriptome data from the single-arm, phase 2 DREAM trial (N = 54).
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- Male frogs use specific calls to attract mates and avoid competition, with their call characteristics influenced by their size and environment.
- The acoustic adaptation hypothesis suggests that frogs evolve their calls to improve their reach and clarity in their habitats.
- Research on Neotropical treefrogs revealed a significant relationship between body size and call frequency, but did not support the AAH claims linking calls to environmental factors, suggesting other influences like female choice may play a role.
Background: Chemo-immunotherapy is standard of care for women with recurrent or advanced mismatch repair deficient endometrial carcinoma. However, it is uncertain whether patients with mismatch repair deficient advanced or recurrent endometrial carcinoma derive less benefit from chemotherapy than those with mismatch repair proficient endometrial carcinoma.
Methods: We performed a meta-analysis of randomized controlled trials (RCTs) in advanced or recurrent endometrial carcinoma to determine the difference in the benefit of chemotherapy in mismatch repair deficient vs mismatch repair proficient endometrial carcinoma.
Article Synopsis
- The study focuses on the OCBIL theory, which examines animal ecology and evolution in old, infertile environments, specifically looking at the endemic toad Oreophrynella quelchii on Roraima-tepui.
- Through tracking and population analysis, the researchers found a surprisingly large population size of around 12 million individuals, which challenges previous assumptions about limited dispersal and small populations.
- The findings suggest that while the toads exhibit reduced dispersibility and resilience to habitat fragmentation, they also indicate robust demographic structures, likely due to the harsh tepui environment.
The remarkable larval morphology of Rhaebo nasicus (Werner, 1903) (Amphibia: Anura: Bufonidae) with the erection of a new bufonid genus and insights into the evolution of suctorial tadpoles.
Zoological Lett
September 2024
Tadpoles serve as crucial evidence for testing systematic and taxonomic hypotheses. Suctorial tadpoles collected in Guyana were initially assigned to Rhaebo nasicus through molecular phylogeny. Subsequent analysis of larval and adult morphological traits revealed synapomorphies within the clade encompassing R.
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