Publications by authors named "P W Cheng"
Background: The H1/H2 haplotype on 17q21.31 represent the foremost genetic factor contributing to the risk of progressive supranuclear palsy (PSP). Various structural forms of 17q21.
View Article and Find Full Text PDFBackground: People leverage single-variant association test to systematically evaluate common genetic variants (minor allele frequency 0.5% < [MAF) < 5%) for complex disease, such as Alzheimer's disease (AD). Rare variants (MAF < 1%) could explain additional disease risk and are known to play an important role in the diseases.
View Article and Find Full Text PDFObjective: This study investigates the impact of Titin (TTN) gene mutations on radiotherapy sensitivity in rectum adenocarcinoma (READ) by examining changes in the tumour immune microenvironment.
Methods: Data on gene expression and mutations in READ were obtained from The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) databases. Bioinformatics analysis explored the correlation between TTN mutations and immune cell infiltration.
Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice.
Arterioscler Thromb Vasc Biol
January 2025
Article Synopsis
- The study investigates the differences between smooth muscle cells (SMCs) from two lineages in the proximal thoracic aorta, specifically the second heart field (SHF) and cardiac neural crest.
- Researchers used advanced techniques like single-cell RNA sequencing and chromatin accessibility assays to analyze these cells in male mice, identifying distinct gene expressions in both lineages.
- Findings reveal that SHF-derived SMCs have unique transcriptomic profiles that may influence their functions in thoracic aortic diseases, suggesting lineage-specific roles in vascular health.