Patients' perceptions of their participation in a clinical trial for postoperative Crohn's disease.

Objective: To explore patients' perceptions of their participation in a randomized controlled trial.

Patients And Methods: A 27-item questionnaire was mailed to all patients who participated in a randomized controlled trial that determined the effectiveness of mesalamine in preventing the recurrence of Crohn's disease postoperatively.

Results: The response rate was 66% (99 of 149).

Risk and significance of endoscopic/radiological evidence of recurrent Crohn's disease.

Background & Aims: The aim of this study was to determine the risk of endoscopic/radiological recurrence of Crohn's disease postoperatively and the long-term outcome.

Methods: A randomized placebo-controlled trial was performed to determine the effectiveness of mesalamine in preventing recurrent Crohn's disease postoperatively. Patients in the control group were examined endoscopically/radiologically before entry into and annually during the trial.

Prophylactic mesalamine treatment decreases postoperative recurrence of Crohn's disease.

Background & Aims: Recurrence of Crohn's disease frequently occurs after surgery. A randomized controlled trial was performed to determine if mesalamine is effective in decreasing the risk of recurrent Crohn's disease after surgical resection is performed.

Methods: One hundred sixty-three patients who underwent a surgical resection and had no evidence of residual disease were randomized to a treatment group (1.