Publications by authors named "P W Ashton"
Article Synopsis
- Researchers have identified the first two enterotoxigenic E. coli (ETEC) genomes from Malawi, isolated in 2014.
- These genomes were taken from the feces of children who were infected but did not show symptoms.
- The genomes contain a version of the heat-labile toxin found in pigs, but lack any recognized ETEC colonization factors.
Background: A predominantly endoscopic approach for acute admissions with choledocholithiasis with a gallbladder in situ (CGIS) resulted in prolonged hospital length of stay due to delays at investigation and treatment junctures. We initiated a quality improvement program of trans-cystic biliary stenting to facilitate efficient patient progress to acute cholecystectomy and outpatient ERCP if required.
Methods: We utilized implementation frameworks with regular re-assessment for this quality improvement project.
Indonesia has the third highest number of tuberculosis (TB) patients infected with Mycobacterium tuberculosis (MTB) Lineage 1 (L1). Most of these MTB L1 cases can be found in Indonesia's remote easternmost province of Papua, one of Indonesia's most underdeveloped provinces with a particularly high burden for TB. In this study, we sequenced and described 42 MTB L1 isolates from a well-characterized cohort of patients.
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- Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A, poses a significant public health issue due to rising antimicrobial resistance, complicating treatment options and worsening health outcomes.
- *The study sequenced bacteria samples from blood cultures of febrile patients in urban sites of Dhaka (Bangladesh), Kathmandu (Nepal), and Blantyre (Malawi) to analyze their genetic characteristics and resistance mechanisms.
- *Findings revealed that different genotypes of S. Typhi were present across the sites, with high rates of multidrug resistance in Blantyre and Dhaka but not in Kathmandu, highlighting diverse transmission dynamics and resistance patterns.