Acetylated α-tubulin K394 regulates microtubule stability to shape the growth of axon terminals.

Microtubules are essential to neuron shape and function. Acetylation of tubulin has the potential to directly tune the behavior and function of microtubules in cells. Although proteomic studies have identified several acetylation sites in α-tubulin, the effects of acetylation at these sites remains largely unknown.

The development of a nursing subset of patient problems to support interoperability.

Background: Since the emergence of electronic health records, nursing information is increasingly being recorded and stored digitally. Several studies have shown that a wide range of nursing information is not interoperable and cannot be re-used in different health contexts. Difficulties arise when nurses share information with others involved in the delivery of nursing care.

The Costs and Benefits of SNOMED CT Implementation: An Economic Assessment Model.

As part of its investigations, the EU-funded ASSESS CT project developed an Economic Assessment Model for assessing SNOMED CT's and other terminologies' socio-economic impact in a systematic approach. Methodology and key elements of the model are presented: cost and benefit indicators for assessing deployment, and a cost-benefit analysis tool to collect, estimate, and evaluate data.

Prospective randomized study of N-acetylcysteine, fenoldopam, and saline for prevention of radiocontrast-induced nephropathy.

The objective of this study was to compare the efficacy of N-acetylcysteine (NAC), fenoldopam, and saline in preventing radiocontrast-induced nephropathy (RCIN) in high-risk patients undergoing cardiovascular procedures. We prospectively enrolled 123 patients who were scheduled for cardiovascular procedures and had a baseline creatinine > 1.6 mg/dl or creatinine clearance of < 60 ml/min.

Comparison of free range and graded exercise testing.

Previous studies with athletes have demonstrated greater physiologic responses during free range (FR) compared with graded (GXT) exercise testing. Since the sensitivity of clinical exercise testing depends upon the magnitude of physiologic responses, we sought to determine whether FR might provoke greater responses than GXT in nonathletic individuals and patients. Healthy, physically active nonathletes and clinically stable CHD patients (N = 12) performed GXT on cycle ergometer (15 W + 15 W.