Publications by authors named "P Vinci"
Article Synopsis
- - Hormonal doping, particularly in recreational bodybuilding, poses a public health risk, prompting efforts by WADA to create the Athlete Biological Passport for monitoring doping patterns.
- - A study of 92 male bodybuilders found that 43% reported regular hormone abuse, linking it to lower HDL-cholesterol levels and higher liver enzyme markers compared to controls.
- - Findings indicate that insulin and growth hormone abuse leads to notable metabolic changes, highlighting the need for further research on the long-term effects of these practices.
Corticosteroid treatment (CST) failure is associated with poor outcomes for patients with gastrointestinal (GI) graft-versus-host disease (GVHD). CST is intended to target the immune system, but the glucocorticoid receptor (GR) is widely expressed, including within the intestines, where its effects are poorly understood. Here, we report that corticosteroids (CS) directly targeted intestinal epithelium, potentially worsening immune-mediated GI damage.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the differences in cardiovascular disease occurrence between patients with polygenic hypercholesterolemia who have high levels of Lp(a) (H-Lpa) versus those with polygenic hypercholesterolemia alone (H-LDL).
- A retrospective analysis of 258 H-Lpa patients and 290 H-LDL patients revealed that those with high Lp(a) experienced vascular events more frequently and at a younger age despite similar LDL cholesterol reductions.
- Men with H-Lpa showed a significantly higher risk of acute coronary artery disease, while women with H-Lpa faced a higher incidence of peripheral artery disease linked to smoking.
Background And Aims: Muscle inactivity leads to muscle atrophy and insulin resistance. The branched-chain amino acid (BCAA) leucine interacts with the insulin signaling pathway to modulate glucose metabolism. We have tested the ability of a high-protein BCAA-enriched diet to prevent insulin resistance during long-term bed rest (BR).
View Article and Find Full Text PDFLipoprotein(a) as a Risk Factor for Cardiovascular Diseases: Pathophysiology and Treatment Perspectives.
Int J Environ Res Public Health
September 2023
Cardiovascular disease (CVD) is still a leading cause of morbidity and mortality, despite all the progress achieved as regards to both prevention and treatment. Having high levels of lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular disease that operates independently. It can increase the risk of developing cardiovascular disease even when LDL cholesterol (LDL-C) levels are within the recommended range, which is referred to as residual cardiovascular risk.
View Article and Find Full Text PDF