Publications by authors named "P Villoslada"
The rate of success of epilepsy surgery, ensuring seizure-freedom, is limited by the lack of epileptogenicity biomarkers. Previous evidence supports the critical role of functional connectivity during seizure generation to characterize the epileptogenic network (EN). However, EN dynamics is highly variable across patients, hindering the development of diagnostic biomarkers.
View Article and Find Full Text PDFRetinal Damage and Visual Network Reconfiguration Defines Visual Function Recovery in Optic Neuritis.
Neurol Neuroimmunol Neuroinflamm
November 2024
Background And Objectives: Recovery of vision after acute optic neuritis (AON) is critical to improving the quality of life of people with demyelinating diseases. The objective of the study was to prospectively assess the changes in visual acuity, retinal layer thickness, and cortical visual network in patients with AON to identify the predictors of permanent visual disability.
Methods: We studied a prospective cohort of 88 consecutive patients with AON with 6-month follow-up using high and low-contrast (2.
Retinal Changes in Double-Antibody Seronegative Neuromyelitis Optica Spectrum Disorders.
Neurol Neuroimmunol Neuroinflamm
September 2024
Article Synopsis
- The study aimed to describe the clinical features of double-antibody seronegative neuromyelitis optica spectrum disorders (DN-NMOSD), focusing on how these disorders affect the retina.
- Researchers analyzed data from 25 individuals with DN-NMOSD and compared it to those with aquaporin-4 antibody positive neuromyelitis optica (AQP4-NMOSD) and healthy controls, using optical coherence tomography (OCT) to assess retinal damage.
- The findings revealed significant thinning of the retinal nerve fiber layer and ganglion cell layers in DN-NMOSD patients, even after just one optic neuritis episode, indicating severe retinal damage and neurodegeneration regardless of an ON history.
Article Synopsis
- The study aims to evaluate how age-adjusted scores from retinal optical coherence tomography (OCT) can predict future disease activity and disability worsening in people with multiple sclerosis (PwMS).
- Researchers created age-adjusted reference values for specific retinal measurements using data from healthy eyes and transformed existing data from PwMS into these scores for comparison.
- Results showed that lower scores (pRNFL-z) were linked to a greater risk of disability worsening, with significant findings from two different cohorts highlighting the importance of retinal imaging in assessing MS progression.