Publications by authors named "P Villarejo"
GECOP-MMC: phase IV randomized clinical trial to evaluate the efficacy of hyperthermic intraperitoneal chemotherapy (HIPEC) with mytomicin-C after complete surgical cytoreduction in patients with colon cancer peritoneal metastases.
BMC Cancer
May 2022
Background: The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefit provided by HIPEC with oxaliplatin 460 mg/m (30 minutes) for the treatment of peritoneal metastases from colorectal cancer. However, several methodological flaws have been identified in PRODIGE 7, specially the HIPEC protocol or the choice of overall survival as the main endpoint, so its results have not been assumed as definitive, emphasizing the need for further research on HIPEC. It seems that the HIPEC protocol with high-dose mytomicin-C (35 mg/m) is the preferred regime to evaluate in future clinical studies.
View Article and Find Full Text PDFPurpose: Obesity is a risk factor for developing abdominal wall hernias and is associated with major postoperative complications, such as surgical site infection, delayed wound healing and recurrent hernia. Therefore, treating incisional hernia in this patient subgroup is a challenge.
Methods: We conducted a comparative, prospective study on patients who underwent primary ventral hernia surgery or incisional hernia surgery through the extended totally extraperitoneal pathway, with body mass indices (BMIs) ≤ 30 (no obesity) and BMI > 30 (with obesity).
Article Synopsis
- Acellular pseudomyxoma peritonei (PMP) is a rare cancer marked by the accumulation of mucin in the peritoneal cavity without tumor cells, leading to significant amounts being analyzed by pathologists.
- A study on three patients revealed mutations in mucin-derived cell-free DNA (cfDNA) that weren't found in their plasma pre or post-surgery, suggesting that these mutations could be tracked via liquid biopsy.
- The findings indicate that while all mucins had similar bacterial profiles and slight cytokine level changes were observed in mice, the presence of mutated cfDNA in mucin might give insights into PMP recurrence and prognosis beyond standard pathological evaluations.
[Development of animal experimental model for bacterial peritonitis].
Rev Esp Quimioter
February 2020
Objective: The aim of the study was to develop a model of abdominal sepsis in the experimental animal.
Methods: Sprague-Dawley male rats of 5 weeks (N=39) were used. Initially, a pilot study (N = 9) was performed and distributed in 3 groups with 1cc inoculum of Escherichia coli ATCC 25922 intraperitoneally at concentrations of 10E8, 10E9 and 10E10 CFU.
Background: In some patients with peritoneal carcinomatosis, we could perform the cytoreductive surgery and the HIPEC procedure by a complete laparoscopic approach to avoid morbidity. We consider that using laparoscopic approach for performing peritoneal carcinomatosis cytoreductive surgery and HIPEC with closed CO recirculation technique is possible and safe, with equal efficacy to conventional methods and hemodynamic complications.
Objective: Monitoring the effectiveness of the drug distribution in a laparoscopic ctoreductive and HIPEC surgery group with CO recirculation respect to a closed and open HIPEC group METHODS: Porcine model that included fifteen mini-pigs.